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Jia-Ning Xiang

from Palo Alto, CA
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Related to:
Lijun WangJ Xiang, 63Jia N XiangLi J Wang, 61Jia N Xiang, 63
Connected to:
Ai Xiang, 64Bangping Xiang, 57James Xiang, 51Jenny X Xiang, 34Jianwei Xiang, 54John E Xiang, 67Lifeng Xiang, 60Liz S Xiang, 41Ni Xiang, 51Shan Xiang, 67

Jia-Ning Xiang Phones & Addresses

  • 1837 Bryant St, Palo Alto, CA 94301 (650) 704-7193

Publications

Us Patents

Peptide Deformylase Inhibitors

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US Patent:
6797730, Sep 28, 2004
Filed:
Feb 18, 2004
Appl. No.:
10/469515
Inventors:
Jia-Ning Xiang - Palo Alto CA
Jinhwa Lee - Collegeville PA
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 3119
US Classification:
514575, 560 24
Abstract:
Novel PDF inhibitors and novel methods for their use are provided.

Prodrugs Of Gaba Analogs, Compositions And Uses Thereof

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US Patent:
6818787, Nov 16, 2004
Filed:
Jun 11, 2002
Appl. No.:
10/171485
Inventors:
Mark A. Gallop - Los Altos CA
Kenneth C. Cundy - Redwood City CA
Cindy X. Zhou - Palo Alto CA
Fenmei Yao - Mountain View CA
Jia-Ning Xiang - Palo Alto CA
Assignee:
Xenoport, Inc. - Santa Clara CA
International Classification:
C07C27122
US Classification:
560115
Abstract:
The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.

Peptide Deformylase Inhibitors

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US Patent:
6897233, May 24, 2005
Filed:
Mar 1, 2002
Appl. No.:
10/469560
Inventors:
Jia-Ning Xiang - Palo Alto CA, US
Xiangmin Liao - Collegeville PA, US
Maxwell D. Cummings - Strafford PA, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C07D207/12
A61K031/40
US Classification:
514424, 548550
Abstract:
PDF inhibitors and novel methods for their use are provided.

Methods For Synthesis Of Prodrugs From 1-Acyl-Alkyl Derivatives And Compositions Thereof

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US Patent:
6927036, Aug 9, 2005
Filed:
Jun 11, 2002
Appl. No.:
10/167797
Inventors:
Mark A. Gallop - Los Altos CA, US
Jia-Ning Xiang - Palo Alto CA, US
Fenmei Yao - Mountain View CA, US
Laxminarayan Bhat - Santa Clara CA, US
Cindy X. Zhou - Palo Alto CA, US
Assignee:
Xero Port, Inc. - Santa Clara CA
International Classification:
C07C271/10
C07D215/227
C07D233/50
C07D235/32
C07H015/236
US Classification:
435 129, 532 136, 546157, 5483091, 5483321, 560 24, 560 33, 560148
Abstract:
Disclosed is a method for synthesizing 1-(acyloxy)-alkyl derivatives of primary or secondary amine drugs from 1-acyl-alkyl derivatives of primary or secondary amine drugs, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amenable to scale-up. For example, 1-acyl-alkyl derivatives of gabapentin and pregabalin are oxidized to yield 1-(acyloxy)-alkyl derivatives of gabapentin and pregabalin, respectively.

Prodrugs Of Gaba Analogs, Compositions And Uses Thereof

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US Patent:
6972341, Dec 6, 2005
Filed:
Jun 10, 2003
Appl. No.:
10/459242
Inventors:
Mark A. Gallop - Los Altos CA, US
Kenneth C. Cundy - Redwood City CA, US
Cindy X. Zhou - Palo Alto CA, US
Fayang G. Qiu - Mountain View CA, US
Fenmei Yao - Mountain View CA, US
Jia-Ning Xiang - Palo Alto CA, US
Ian R. Ollman - San Mateo CA, US
Assignee:
Xeno Port, Inc. - Santa Clara CA
International Classification:
C07C269/00
C07C271/00
US Classification:
560157, 560160
Abstract:
The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.

Peptide Deformylase Inhibitors

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US Patent:
7019003, Mar 28, 2006
Filed:
Mar 1, 2002
Appl. No.:
10/469433
Inventors:
Jia-Ning Xiang - Palo Alto CA, US
Jinhwa Lee - Collegeville PA, US
Daniel J. Mercer - Collegeville PA, US
Assignee:
Smithkline Beecham Corporation - Philadelphia PA
International Classification:
A61K 31/535
C07C 271/00
US Classification:
5142348, 5142375, 5142378, 51425501, 5142581, 514277, 514311, 514315, 514330, 514351, 514359, 514394, 514411, 514415, 562555, 562621, 544162, 544335, 544355, 544390, 546122, 546146, 546159, 546169, 546245, 546254, 546316, 548261, 5483014, 5483044, 5483094, 548429, 548492, 548507, 549159, 549362, 549365, 549366, 549424, 549469, 549487
Abstract:
Novel PDF inhibitors and novel methods for their use are provided.

Cyclic 1-(Acyloxy)-Alkyl Prodrugs Of Gaba Analogs, Compositions And Uses Thereof

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US Patent:
7026351, Apr 11, 2006
Filed:
Mar 20, 2003
Appl. No.:
10/393806
Inventors:
Mark A Gallop - Los Altos CA, US
Jia-Ning Xiang - Palo Alto CA, US
Fenmei Yao - Mountain View CA, US
Laxminarayan Bhat - Santa Clara CA, US
Assignee:
Xenoport, Inc. - Santa Clara CA
International Classification:
A61K 31/35
A61K 31/335
C07D 307/00
C07D 313/00
C07D 307/78
US Classification:
514450, 514459, 514460, 514471, 549304, 549305, 549266, 549271, 549292, 549307, 549318
Abstract:
The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.

Carbidopa Prodrugs And Derivatives, And Compositions And Uses Thereof

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US Patent:
7101912, Sep 5, 2006
Filed:
Dec 8, 2003
Appl. No.:
10/728942
Inventors:
Jia-Ning Xiang - Palo Alto CA, US
Mark A. Gallop - Los Altos CA, US
Kenneth C. Cundy - Redwood City CA, US
Jianhua Li - Sunnyvale CA, US
Feng Xu - Palo Alto CA, US
Cindy X. Zhou - Palo Alto CA, US
Laxminarayan Bhat - Santa Clara CA, US
Assignee:
XenoPort, Inc. - Santa Clara CA
International Classification:
A61K 31/216
C07C 229/28
US Classification:
514533, 514538, 514450, 514452, 514456, 514466, 514469, 514470, 514471, 549229, 549267, 549274, 549436, 549438, 549444, 549304, 549310, 549292, 549313, 558269, 560 34
Abstract:
Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed.
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Jia-Ning Xiang from Palo Alto, CA Get Report