US Patent:
20080200445, Aug 21, 2008
Inventors:
Zhaoning Zhu - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan Ye - Edison NJ, US
Johannes Voigt - Cranford NJ, US
Corey Strickland - Martinsville NJ, US
Elizabeth Smith - Verona NJ, US
Andrew Stamford - Chatham Township NJ, US
William Greenlee - Teaneck NJ, US
Robert Mazzola - Stewartsville NJ, US
John Caldwell - Ringwood NJ, US
Jared Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Xiaoxiang Liu - River Vale NJ, US
Tao Guo - Dayton NJ, US
Thuy Le - Monmouth Junction NJ, US
Kurt Saionz - Cranford NJ, US
Suresh Babu - Plainsboro NJ, US
Rachael Hunter - Princeton NJ, US
Michelle Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - East Windsor NJ, US
Ying Huang - East Brunswick NJ, US
Guoqing Li - Belle Mead NJ, US
Jianping Pan - Monmouth Junction NJ, US
Jeffrey Misiaszek - Kenilworth NJ, US
Gaifa Lai - Monmouth Junction NJ, US
Jingqi Duo - Monmouth Junction NJ, US
Chuanxing Qu - Scotch Plains NJ, US
Yuefei Shao - Princeton NJ, US
International Classification:
A61K 31/506
A61K 31/4178
A61K 31/4245
A61K 31/4439
A61K 31/454
A61K 31/541
A61P 31/00
C07D 233/02
C07D 271/00
C07D 413/14
C07D 409/14
C07D 409/04
C07D 403/06
C07D 401/14
C07D 401/12
C07D 401/10
C07D 401/06
C07D 239/04
A61P 9/00
A61P 25/00
A61K 31/5377
A61K 31/4545
A61K 31/4709
A61K 31/498
US Classification:
514210020, 514222200, 514229200, 514235800, 514249000, 514272000, 514313000, 514318000, 514326000, 514341000, 514389000, 544295000, 544321000, 544066000, 546162000, 546194000, 546210000, 546274400, 546297000, 548314400, 548550000
Abstract:
Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.