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Jeffrey Arthur Misiaszek

from Somerset, NJ
Age ~42

Jeffrey Misiaszek Phones & Addresses

  • 28 Rue Chagall, Somerset, NJ 08873 (732) 659-6297
  • North Brunswick, NJ
  • Kenilworth, NJ
  • 6 Lantern Ln, Old Lyme, CT 06371 (860) 434-8900
  • Vernon Rockville, CT
  • 314 N 11Th St, Kenilworth, NJ 07033 (908) 327-4081

Work

Position: Protective Service Occupations

Education

Degree: High school graduate or higher

Emails

j***k@worldnet.att.net

Publications

Us Patents

Heterocyclic Aspartyl Protease Inhibitors

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US Patent:
20080200445, Aug 21, 2008
Filed:
Feb 23, 2007
Appl. No.:
11/710582
Inventors:
Zhaoning Zhu - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan Ye - Edison NJ, US
Johannes Voigt - Cranford NJ, US
Corey Strickland - Martinsville NJ, US
Elizabeth Smith - Verona NJ, US
Andrew Stamford - Chatham Township NJ, US
William Greenlee - Teaneck NJ, US
Robert Mazzola - Stewartsville NJ, US
John Caldwell - Ringwood NJ, US
Jared Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Xiaoxiang Liu - River Vale NJ, US
Tao Guo - Dayton NJ, US
Thuy Le - Monmouth Junction NJ, US
Kurt Saionz - Cranford NJ, US
Suresh Babu - Plainsboro NJ, US
Rachael Hunter - Princeton NJ, US
Michelle Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - East Windsor NJ, US
Ying Huang - East Brunswick NJ, US
Guoqing Li - Belle Mead NJ, US
Jianping Pan - Monmouth Junction NJ, US
Jeffrey Misiaszek - Kenilworth NJ, US
Gaifa Lai - Monmouth Junction NJ, US
Jingqi Duo - Monmouth Junction NJ, US
Chuanxing Qu - Scotch Plains NJ, US
Yuefei Shao - Princeton NJ, US
International Classification:
A61K 31/506
A61K 31/4178
A61K 31/4245
A61K 31/4439
A61K 31/454
A61K 31/541
A61P 31/00
C07D 233/02
C07D 271/00
C07D 413/14
C07D 409/14
C07D 409/04
C07D 403/06
C07D 401/14
C07D 401/12
C07D 401/10
C07D 401/06
C07D 239/04
A61P 9/00
A61P 25/00
A61K 31/5377
A61K 31/4545
A61K 31/4709
A61K 31/498
US Classification:
514210020, 514222200, 514229200, 514235800, 514249000, 514272000, 514313000, 514318000, 514326000, 514341000, 514389000, 544295000, 544321000, 544066000, 546162000, 546194000, 546210000, 546274400, 546297000, 548314400, 548550000
Abstract:
Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.

Iminothiadiazine Dioxide Compounds As Bace Inhibitors, Compositions And Their Use

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US Patent:
20120183563, Jul 19, 2012
Filed:
Oct 6, 2010
Appl. No.:
13/392297
Inventors:
Jack D. Scott - Scotch Plains NJ, US
Andrew W. Stamford - Chatham NJ, US
Eric J. Gilbert - Scotch Plains NJ, US
Jared N. Cumming - Garwood NJ, US
Ulrich Iserloh - Hoboken NJ, US
Jeffrey A. Misiaszek - Somerset NJ, US
Guoqing Li - Belle Mead NJ, US
International Classification:
A61K 31/549
C07D 285/18
C07D 417/14
C07D 471/04
C07D 495/04
A61K 31/55
A61K 39/395
A61K 39/00
A61P 29/00
A61P 31/04
A61P 37/04
A61P 5/50
A61P 25/28
A61P 25/16
A61P 25/00
A61P 3/10
C07D 417/04
A61P 7/04
A61P 7/00
C07D 417/12
US Classification:
4241721, 544 8, 5142225, 514215, 4241841
Abstract:
In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): (I) and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R, R, R, R, R, R, ring A, ring B, m, n, p, -L-,L-, and L- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (Aβ) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimers disease, are also disclosed.

Heterocyclic Aspartyl Protease Inhibitors

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US Patent:
20120231017, Sep 13, 2012
Filed:
Mar 8, 2012
Appl. No.:
13/415404
Inventors:
ZHAONING ZHU - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan C. Ye - Edison NJ, US
Johannes H. Voigt - Cranford NJ, US
Corey O. Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham NJ, US
William J. Greenlee - Teaneck NJ, US
Robert D. Mozzola - Stewartsville NJ, US
John P. Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Tao Guo - Dayton NJ, US
Thuy X. E. Le - Monmouth Junction NJ, US
Kurt W. Sainoz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Rachael C. Hunter - Princeton NJ, US
Michelle L. Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - East Windsor NJ, US
Ying Huang - East Brunswick NJ, US
Guoqing Li - Belle Mead NJ, US
Jianping Pan - Monmouth Junction NJ, US
Jeffrey A. Misiaszek - Kenilworth NJ, US
Gaifa Lai - Monmouth Junction NJ, US
Jingqi Duo - Monmouth Junction NJ, US
Chuanxing Qu - Scotch Plains NJ, US
Yuefei Shao - Princeton NJ, US
Assignee:
Pharmacopeia Inc. - La Jolla CA
Schering Corporation - Rahway NJ
International Classification:
A61K 39/395
C07D 239/70
C07F 5/02
C07D 403/10
A61K 31/513
A61K 31/506
C07D 409/04
C07D 409/14
C07D 401/04
C07D 405/14
C07D 417/14
C07D 417/04
C07D 413/14
C07D 413/10
A61K 31/5377
A61P 29/00
A61P 9/00
A61P 25/28
A61P 31/10
A61P 33/02
C07D 495/04
A61P 25/00
A61P 31/04
C07D 239/22
US Classification:
4241721, 544321, 544231, 544229, 514272, 544295, 51425505, 544123, 5142358, 5142102
Abstract:
Disclosed are compounds of the formula Ior a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.

Heterocyclic Aspartyl Protease Inhibitors

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US Patent:
20120231018, Sep 13, 2012
Filed:
Mar 9, 2012
Appl. No.:
13/416140
Inventors:
Zhaoning Zhu - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan C. Ye - Edison NJ, US
Johannes H. Voigt - Cranford NJ, US
Corey O. Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham NJ, US
William J. Greenlee - Teaneck NJ, US
Robert D. Mozzola - Stewartsville NJ, US
John P. Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Xiaoxiang Liu - River Vale NJ, US
Tao Guo - Dayton NJ, US
Thuy X. E. Le - Monmouth Junction NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Rachael C. Hunter - Princeton NJ, US
Michelle L. Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - East Windsor NJ, US
Ying Huang - East Brunswick NJ, US
Guoqing Li - Belle Mead NJ, US
Jianping Pan - Monmouth Junction NJ, US
Jeffrey A. Misiaszek - Kenilworth NJ, US
Gaifa Lai - Monmouth Junction NJ, US
Jingqi Duo - Monmouth Junction NJ, US
Chuanxing Qu - Scotch Plains NJ, US
Yuefei Shao - Princeton NJ, US
Assignee:
Pharmacopeia Inc. - La Jolla CA
Schering Corporation - Rahway NJ
International Classification:
A61K 31/513
A61P 25/28
A61P 31/10
A61P 25/00
A61P 29/00
A61K 39/395
A61P 31/04
A61P 9/00
A61P 33/02
US Classification:
4241721, 514272
Abstract:
Disclosed are compounds of the formula Ior a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.

Heterocyclic Aspartyl Protease Inhibitors

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US Patent:
20120276118, Nov 1, 2012
Filed:
Mar 14, 2012
Appl. No.:
13/420007
Inventors:
Zhaoning Zhu - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan C. Ye - Edison NJ, US
Johannes H. Voight - Cranford NJ, US
Corey O. Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham NJ, US
William J. Greenlee - Teaneck NJ, US
Robert D. Mazzola - Stewartsville NJ, US
John P. Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Xiaoxiang Liu - River Vale NJ, US
Tao Guo - Dayton NJ, US
Thuy X.E. Le - Monmouth Junction NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Rachael C. Hunter - Princeton NJ, US
Michelle L. Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - East Windsor NJ, US
Ying Huang - East Brunswick NJ, US
Guoqing Li - Belle Mead NJ, US
Jianping Pan - Monmouth Junction NJ, US
Jeffrey A. Misiaszek - Kenilworth NJ, US
Gaifa Lai - Monmouth Junction NJ, US
Jingqi Duo - Monmouth Junction NJ, US
Chuanxing Qu - Scotch Plains NJ, US
Yuefei Shao - Princeton NJ, US
Assignee:
Pharmacopeia Inc. - La Jolla CA
Schering Corporation - Rahway NJ
International Classification:
A61K 39/395
US Classification:
4241721
Abstract:
Disclosed are compounds of the formula Ior a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.

Iminothiadiazine Dioxide Compounds As Bace Inhibitors, Compositions And Their Use

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US Patent:
20150307465, Oct 29, 2015
Filed:
Feb 27, 2015
Appl. No.:
14/633952
Inventors:
- Rahway NJ, US
Andrew W. Stamford - Chatham NJ, US
Eric J. Gilbert - Scotch Plains NJ, US
Jared N. Cumming - Garwood NJ, US
Ulrich Iserloh - Hoboken NJ, US
Jeffrey A. Misiaszek - Somerset NJ, US
Guoqing Li - Belle Mead NJ, US
Assignee:
MERCK SHARP & DOHME CORP. - Rahway NJ
International Classification:
C07D 285/18
C07D 417/10
C07D 487/04
C07D 417/14
C07D 471/04
C07D 495/04
C07D 417/04
C07D 417/12
Abstract:
In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I):and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R, R, R, R, R, R, ring A, ring B, m, n, p, -L-, -L-, and -L- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (“Aβ”) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's disease, are also disclosed.

Iminothiadiazine Dioxide Compounds As Bace Inhibitors, Compositions, And Their Use

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US Patent:
20140206675, Jul 24, 2014
Filed:
Mar 21, 2014
Appl. No.:
14/221650
Inventors:
- Rahway NJ, US
Andrew W. Stamford - Chatham NJ, US
Eric J. Gilbert - Scotch Plains NJ, US
Jared N. Cumming - Garwood NJ, US
Ulrich Iserloh - Hoboken NJ, US
Jeffrey A. Misiaszek - Somerset NJ, US
Guoqing Li - Belle Mead NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 285/18
C07D 417/10
C07D 495/04
C07D 417/14
C07D 471/04
C07D 417/04
C07D 417/12
US Classification:
5142225
Abstract:
In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): (I) and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R, R, R, R, R, R, ring A, ring B, m, n, p, -L-, L-, and L- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (Aβ) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination nation with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimers disease, are also disclosed.
Jeffrey Arthur Misiaszek from Somerset, NJ, age ~42 Get Report