Jay S Teich

7276351, Oct 2, 2007

Oct 17, 2003

10/688791

Jay S. Teich - Weston MA, US
Andy C. Neilson - Groton MA, US
Michael R. Sweeney - Pelham NH, US
Geoff Uhl - Cambridge MA, US

Seahorse Bioscience - Billerica MA

G01N 1/30
G01N 33/48

435 4051

A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.

7638321, Dec 29, 2009

Jun 1, 2007

11/809752

Jay S. Teich - Weston MA, US
Andy C. Neilson - Groton MA, US
Michael R. Sweeney - Pelham NH, US
Geoff Uhl - Cambridge MA, US

Seahorse Bioscience, Inc. - North Billerica MA

C12M 1/34

4352871

A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.

7851201, Dec 14, 2010

Nov 9, 2009

12/614773

Jay S. Teich - Berlin MA, US
Andy C. Neilson - Groton MA, US
Michael R. Sweeney - Pelham NH, US
Geoff Uhl - Littleton CO, US

Seahorse Bioscience, Inc. - Billerica MA

C12M 1/34

4352871

A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.

20020098592, Jul 25, 2002

Feb 5, 2001

09/777363

Andy Neilson - Groton MA, US
Jay Teich - Weston MA, US

FLIR Systems Boston, Inc.

G01N025/20

436/147000, 422/102000, 422/104000, 422/051000, 250/363020, 374/031000, 374/043000

Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.

20020098593, Jul 25, 2002

Feb 5, 2001

09/777368

Andy Nelson - Groton MA, US
Jay Teich - Weston MA, US

FLIR Systems Boston, Inc.

G01N025/20

436/147000, 436/149000, 436/164000, 422/102000, 422/051000

Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.

20020132360, Sep 19, 2002

Jan 17, 2001

09/764963

Andy Neilson - Groton MA, US
Jay Teich - Weston MA, US

FLIR Systems Boston, Inc.

B01L003/00
G01N025/20

436/147000, 422/055000, 422/102000

Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.

20040107986, Jun 10, 2004

Dec 6, 2002

10/313917

Andy Neilson - Groton MA, US
Jay Teich - Weston MA, US
Mike Sweeney - Stoneham MA, US

H01L035/30
H01L035/28

136/204000, 136/205000

A system is provided to enable high throughput parallel processing of multiple samples for drug screening methods and other analytical methods. Disposable wellplates cooperate with external sensor arrays to eliminate the laborious task of cleaning and sterilizing contaminated system components. The wellplates can use conventional or custom array formats, and are adapted and configured to be well suited for high throughput automated analytical screening processes.

20070087401, Apr 19, 2007

Oct 10, 2006

11/545714

Andy Neilson - Groton MA, US
Jay Teich - Berlin MA, US
Min Wu - Carlisle MA, US
David Ferrick - Carlisle MA, US

C12Q 1/02

435029000

Disclosed are methods for non-destructively measuring in vitro the effect on cellular metabolism of the addition to animal cells in culture of a soluble molecule potentially capable of perturbing the biological state of the cells, such as a drug or drug candidate, a toxin, a ligand known or suspected to bind to a cell surface receptor, a nutrient, a cytokine, a growth factor, a chemokine, a metabolism inhibitor or stimulator. Also disclosed are methods for measuring cell viability, vitality, or quality, e.g., in anticipation of the execution of an experiment on the cells. The measurements are done by observing alteration in the rates of consumption or production of extracellular solutes related to aerobic and anaerobic cellular metabolism, such as oxygen, protons, nutrients, carbon dioxide, lactate, or lactic acid. The methods are particularly useful in drug discovery efforts, such as cancer drug discovery and searches for modulators of cellular metabolism.