Search

Jane Sottile Phones & Addresses

  • 52 Pavilion St, Rochester, NY 14620
  • 10 Oak Leaf Ln, Pittsford, NY 14534
  • 62 Hollywood Ave, Albany, NY 12208 (518) 489-7156
  • Hyde Park, NY
  • Madison, WI

Publications

Us Patents

Treatment Of Fibrosis-Related Disorders Using Fibronectin Binding Proteins And Polypeptides

View page
US Patent:
20130190224, Jul 25, 2013
Filed:
Feb 3, 2011
Appl. No.:
13/576900
Inventors:
Jane Sottile - Rochester NY, US
Inaam Nakchbandi - Munich, DE
Burns C. Blaxall - Cincinnati OH, US
Assignee:
MAX-PLANCK-GESELLSCHAFT zur FORDERUNG der WISSENSCHAFTEN e.V. - Munich
UNIVERSITY OF ROCHESTER - Rochester NY
International Classification:
A61K 38/16
US Classification:
514 17, 514 93, 514 19
Abstract:
The present invention is directed to various uses of fibronectin binding proteins or polypeptides for treating and preventing fibrosis and fibrosis related conditions. The fibronectin binding proteins and polypeptides are also useful for treating conditions associated with vascular remodeling and cardiac dysfunction.

Fibronectin Purification Vector

View page
US Patent:
54609550, Oct 24, 1995
Filed:
Oct 28, 1993
Appl. No.:
8/145061
Inventors:
Deane F. Mosher - Madison WI
Jane M. Sottile - Madison WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C07K 122
C07K 114
C12N 1509
C12N 1563
US Classification:
435 697
Abstract:
Recombinant protein purification vectors and methods for their use are disclosed. The vectors contain a DNA sequence coding for a gelatin binding region of fibronectin. The vectors express a foreign DNA sequence of interest fused to the fibronectin portion. Secretion signals on the fused product assist the product in being secreted from a production cell. The product can then be purified on a gelatin-containing affinity column and digested with a protease, such as trypsin, to cleave the desired protein from the gelatin binding region. The protein then contains no more than one extraneous amino acid.

Fibronectin Purification Vector

View page
US Patent:
53427629, Aug 30, 1994
Filed:
Jan 3, 1991
Appl. No.:
7/637250
Inventors:
Deane F. Mosher - Madison WI
Jane M. Sottile - Madison WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12N 1511
C12N 1566
C07K 312
C07K 318
US Classification:
435 691
Abstract:
Recombinant protein purification vectors and methods for their use are disclosed. The vectors contain a DNA sequence coding for a gelatin binding region of fibronectin. The vectors express a foreign DNA sequence of interest fused to the fibronectin portion. Secretion signals on the fused product assist the product in being secreted from a production cell. The product can then be purified on a gelatin containing affinity column and digested with a protease such as trypsin to cleave the desired protein from the gelatin binding region. The vectors can also be designed to code for factor XIIIa cross liking sites and to have a chemically reactive cysteine residue.
Jane M Sottile from Rochester, NY, age ~67 Get Report