Jan Pohl Phones & Addresses
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Germantown, MD
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7706 Keyport Ter, Derwood, MD 20855
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Rockville, MD
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Tucker, GA
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Washington, DC
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5020 Park Brooke Walk Way, Alpharetta, GA 30022 (678) 319-0107
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Gainesville, FL
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Doraville, GA
Work
Company:
U s dept of health and human services
Address:
1600 Clifton Rd Ne # 4101, Atlanta, GA 30329
Phones:
(404) 639-7200
Position:
Chief biotechnology core
Industries:
Administration of Public Health Programs
Business Records
Name / Title
Company / Classification
Phones & Addresses
Chief Biotechnology Core
U S Dept of Health and Human Services
Administration of Public Health Programs
Administration of Public Health Programs
1600 Clifton Rd Ne # 4101, Atlanta, GA 30329
Chief Biotechnology Core
U S Dept of Health and Human Services
1600 Clifton Rd NE #4101, Atlanta, GA 30329
(404) 639-7200
(404) 639-7200
Chief Biotechnology Core
U S Dept of Health and Human Services
Administration of Public Health Programs
Administration of Public Health Programs
1600 Clifton Rd Ne # 4101, Atlanta, GA 30329
Publications
Us Patents
Biomarkers For Oxidative Stress
View pageUS Patent:
6953666, Oct 11, 2005
Filed:
Nov 5, 1999
Appl. No.:
09/831123
Inventors:
Raymond Shapira - Atlanta GA, US
Peter E. Jensen - Atlanta GA, US
Ngoc-Anh Le - Decatur GA, US
Jan Pohl - Tucker GA, US
W. Virgil Brown - Atlanta GA, US
Peter E. Jensen - Atlanta GA, US
Ngoc-Anh Le - Decatur GA, US
Jan Pohl - Tucker GA, US
W. Virgil Brown - Atlanta GA, US
Assignee:
Emory University - Atlanta GA
International Classification:
G01N033/53
A61K039/395
A61K039/395
US Classification:
435 71, 436512, 435326, 4241301, 5303871, 5303891
Abstract:
This invention related generally to methods of detecting and quantifying biomarkers of oxidative stress in proteins. The biomarker may be any amino acid that has undergone oxidation (or other modification, e. g. chloro-tyrosine, dityrosine). Emphasis is given herein on oxidized sulfur- or selenium-containing amino acids (SSAA). The biomarker of oxidative stress in proteins may be detected with an antibody that binds to oxidized amino acids, specifically oxidized sulfur- or selenium-containing amino acids. The antibody may be monoclonal or polyclonal. The presence of biomarker or amount of biomarker present in a sample may be used to aid in assessing the efficacy of environmental, nutritional and therapeutic interventions, among other uses.
Methods For Determination Of Protein Phosphatase Activity, And Uses In Predicting Therapeutic Outcomes
View pageUS Patent:
20100297666, Nov 25, 2010
Filed:
Jul 31, 2008
Appl. No.:
12/669665
Inventors:
Jennifer L. Gooch - Lilburn GA, US
Brian R. Roberts - Sandy Springs GA, US
Jan Pohl - Tucker GA, US
Brian R. Roberts - Sandy Springs GA, US
Jan Pohl - Tucker GA, US
International Classification:
G01N 33/573
C12Q 1/48
C12Q 1/42
C12Q 1/48
C12Q 1/42
US Classification:
435 74, 435 15, 435 21
Abstract:
One aspect of the present disclosure encompasses methods for determining a protein kinase or phosphatase activity in a biological sample, comprising: contacting in a reaction mix a first test sample and a fluorescently-labeled peptide substrate capable of being modified by a protein phosphatase or a protein kinase, contacting the reaction mix with a TiOmatrix, thereby partitioning fluorescently-labeled phosphorylated peptide from fluorescently-labeled dephosphorylated peptide; and determining the fluorescence of the fluorescently-labeled dephosphorylated peptide, thereby determining a protein kinase or phosphatase activity.
Serologic Correlates Of Protection Against Bacillis Anthracis Infection
View pageUS Patent:
20120308597, Dec 6, 2012
Filed:
Feb 10, 2011
Appl. No.:
13/577878
Inventors:
Vera A. Semenova - Lilburn GA, US
Conrad P. Quinn - Lilburn GA, US
Jan Pohl - Tucker GA, US
Pavel Svoboda - Atlanta GA, US
Conrad P. Quinn - Lilburn GA, US
Jan Pohl - Tucker GA, US
Pavel Svoboda - Atlanta GA, US
Assignee:
Centers for Disease Control and Prevention - Atlanta GA
International Classification:
A61K 39/07
A61P 31/04
G01N 33/566
A61P 31/04
G01N 33/566
US Classification:
4241901, 435 792
Abstract:
Regions of protective antigen are provided representing epitopes recognized by antibodies in subjects that have acquired immunity to infection. The recognition of these epitopes correlates with autoimmunity in a subject. Also provided are vaccines that include at least one of these epitopes that when administered to a subject provide improved acquired immunity.
Methods For Determination Of Protein Phosphatase Activity, And Uses In Predicting Therapeutic Outcomes
View pageUS Patent:
20130122514, May 16, 2013
Filed:
Dec 6, 2012
Appl. No.:
13/706750
Inventors:
Emory University - Atlanta GA, US
Brian R. Roberts - Sandy Springs GA, US
Jan Pohl - Tucker GA, US
Brian R. Roberts - Sandy Springs GA, US
Jan Pohl - Tucker GA, US
Assignee:
EMORY UNIVERSITY - Atlanta GA
International Classification:
C12Q 1/42
US Classification:
435 71, 435 21
Abstract:
One aspect of the present disclosure encompasses methods for determining a protein kinase or phosphatase activity in a biological sample, comprising: contacting in a reaction mix a first test sample and a fluorescently-labeled peptide substrate capable of being modified by a protein phosphatase or a protein kinase, contacting the reaction mix with a TiOmatrix, thereby partitioning fluorescently-labeled phosphorylated peptide from fluorescently-labeled dephosphorylated peptide; and determining the fluorescence of the fluorescently-labeled dephosphorylated peptide, thereby determining a protein kinase or phosphatase activity.
Serologic Correlates Of Protection Against Bacillis Anthracis Infection
View pageUS Patent:
20140004139, Jan 2, 2014
Filed:
Aug 27, 2013
Appl. No.:
14/010668
Inventors:
Conrad P. Quinn - Lilburn GA, US
Jan Pohl - Tucker GA, US
Pavel Svoboda - Atlanta GA, US
Shannon Dalton - Stone Mountain GA, US
Jarad M. Schiffer - Atlanta GA, US
Jan Pohl - Tucker GA, US
Pavel Svoboda - Atlanta GA, US
Shannon Dalton - Stone Mountain GA, US
Jarad M. Schiffer - Atlanta GA, US
Assignee:
Centers for Disease Control and Prevention - Atlanta GA
International Classification:
C07K 14/32
US Classification:
4241901, 435 792
Abstract:
Regions of protective antigen are provided representing sequences recognized by antibodies in subjects that have vaccine induced lethal toxin neutralizing anti-PA IgG responses. The recognition of these PA regions enhances the utility of anti-PA IgG reactivity as an immune correlate of protection against anthrax in a subject and increases predictive probability of survival. Also provided are vaccines that include at least one of these PA regions that when administered to a subject improve the predictive value of vaccine induced anti-PA IgG and TNA responses as immune correlates of protection against inhalation anthrax.
Polycationic Oligomers
View pageUS Patent:
61535966, Nov 28, 2000
Filed:
Dec 18, 1997
Appl. No.:
8/993008
Inventors:
Dennis C. Liotta - McDonough GA
John A. Petros - Norcross GA
Joan F. Karr - Decatur GA
Jan Pohl - Doraville GA
John A. Petros - Norcross GA
Joan F. Karr - Decatur GA
Jan Pohl - Doraville GA
Assignee:
Emory University - Atlanta GA
International Classification:
A01N 4304
US Classification:
514 44
Abstract:
The present invention relates to improved methods for introducing nucleic acid into cells by first complexing the nucleic acid with a selected polycationic oligomer which neutralizes the negative charge of the nucleic acid, and then contacting the cell with the complex facilitating uptake of the nucleic acid into the cells as a complex with the oligomer. The methods are preferably applied to introduction of nucleic acid into eukaryotic cells, and more preferably into human cells. The invention also relates to methods of introducing antisense and triplex-forming oligonucleotides into prostate cancer cells to inhibit expression of proteins associated with (or that promote) malignancy and to inhibit cell growth or proliferation. More particularly, the invention relates to a method for inhibiting the expression of the HER-2/NEU protein in prostate cancer cells and to a method for inhibiting prostate cancer cell growth or proliferation.
Monoclonal Antibody For The Detection Of The Antiretroviral Drug Emtricitabine (Ftc, 2',3'-Dideoxy-5-Fluoro-3'-Thiacytidine)
View pageUS Patent:
20210253738, Aug 19, 2021
Filed:
Jul 10, 2019
Appl. No.:
17/255763
Inventors:
- Bethesda MD, US
Ae Saekhou Youngpairoj - Snellville GA, US
William Marshall Switzer - Decatur GA, US
Walid M. Heneine - Atlanta GA, US
HaoQiang Zheng - Johns Creek GA, US
Jan Pohl - Tucker GA, US
Ae Saekhou Youngpairoj - Snellville GA, US
William Marshall Switzer - Decatur GA, US
Walid M. Heneine - Atlanta GA, US
HaoQiang Zheng - Johns Creek GA, US
Jan Pohl - Tucker GA, US
Assignee:
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC - Bethesda MD
International Classification:
C07K 16/44
G01N 33/577
G01N 33/577
Abstract:
Disclosed are monoclonal antibodies that specifically bind emtricitabine (FTC). Methods are also disclosed for using these antibodies to detect FTC in samples. In some embodiments, these methods are of use for determining if a subject is complying with a therapeutic or prophylactic protocol. In other embodiments, methods are disclosed for determining the dose of FTC to administer to a subject.
Serologic Correlates Of Protection Against Bacillus Anthracis Infection
View pageUS Patent:
20170165344, Jun 15, 2017
Filed:
Feb 21, 2017
Appl. No.:
15/438152
Inventors:
- Rockville MD, US
Pavel Svoboda - Atlanta GA, US
Jan Pohl - Tucker GA, US
Conrad P. Quinn - Lilburn GA, US
Pavel Svoboda - Atlanta GA, US
Jan Pohl - Tucker GA, US
Conrad P. Quinn - Lilburn GA, US
International Classification:
A61K 39/07
Abstract:
Regions of protective antigen are provided representing epitopes recognized by antibodies in subjects that have acquired immunity to infection. The recognition of these epitopes correlates with autoimmunity in a subject. Also provided are vaccines that include at least one of these epitopes that when administered to a subject provide improved acquired immunity.