Inventors:
Gregory D. Cuny - Somerville MA
James R. Hauske - Concord MA
Michele L. R. Heffernan - Worcester MA
Joanne M. Holland - Brookline MA
Paul E. Persons - Westborough MA
Heike Radeke - South Grafton MA
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
A61K 31535
US Classification:
5142368, 51425402, 514326, 514370, 544133, 544137, 544369, 546209, 548190
Abstract:
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various mammalian cellular receptors, including G-protein coupled receptors. A third aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for mammalian dopamine, muscarinic or serotonin receptors or transporters. Another aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for mammalian dopamine, muscarinic or serotonin receptors. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimers disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinsons disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilsons disease, Tourettes syndrome, psychiatric disorders, stroke, senile dementia, peptic ulcers, pulmonary obstruction disorders, and asthma.