US Patent:
20100290982, Nov 18, 2010
Inventors:
Amalendu Prakash Ranjan - Fort Worth TX, US
Anindita Mukerjee - Fort Worth TX, US
Jamboor K. Vishwanatha - Fort Worth TX, US
Assignee:
University of North Texas Health Science Center at Fort Worth - Fort Worth TX
International Classification:
A61K 51/02
A61K 31/713
A61K 39/395
A61K 31/121
A61P 35/00
A61P 31/10
A61P 31/12
A61P 33/10
A61P 31/00
US Classification:
424 111, 514 44 A, 4241301, 514679, 977773, 977906, 977882
Abstract:
The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic stabilizing agent non-covalently associated with a spacer compound that includes at least one electrophile that selectively reacts with any nucleophilic on a targeting agent and places the targeting agent on the exterior surface of a biodegradable nanoparticle, wherein an active agent is encapsulated in or about the nanoparticle.