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Jacob Hesterman Phones & Addresses

  • 54 Court St, Newton, MA 02458
  • Newtonville, MA
  • Brighton, MA
  • Venice, FL
  • Tucson, AZ
  • 35 Turner St #3, Brighton, MA 02135

Publications

Us Patents

Fluorescence Histo-Tomography (Fht) Systems And Methods

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US Patent:
20190154665, May 23, 2019
Filed:
Jan 4, 2019
Appl. No.:
16/239634
Inventors:
- Boston MA, US
John V. Frangioni - Wayland MA, US
Robert William Holt - Boston MA, US
Mohammed Q. Qutaish - Medford MA, US
Marc Edward Seaman - Norwood MA, US
Mark W. Bordo - Worcester MA, US
Jacob Yost Hesterman - Newton MA, US
International Classification:
G01N 33/50
G06T 7/30
H04N 5/247
A61B 5/00
H04N 5/225
G06T 5/00
Abstract:
In one embodiment, a fluorescence histo-tomography (FHT) system is disclosed. The FHT system includes an imaging housing, a fluorescence camera located within the housing, a white light camera located within the imaging housing, and a fluorescence light source located within the imaging housing. The FHT system further includes a support mount configured to support the imaging housing within a chamber of a slicing apparatus such that the cameras and fluorescence light source are aimed towards a block face of a tissue specimen retained within the chamber.

Multi-Spectral Three Dimensional Imaging System And Method

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US Patent:
20180047161, Feb 15, 2018
Filed:
Oct 3, 2017
Appl. No.:
15/723585
Inventors:
- Boston MA, US
Mohammed Q. Qutaish - Medford MA, US
John W. Hoppin - Boston MA, US
Marc E. Seaman - Norwood MA, US
Jacob Y. Hesterman - Newton MA, US
International Classification:
G06T 7/00
G06T 17/00
G01N 23/04
G01N 21/64
G06T 5/00
Abstract:
A processor receives a first image of a first section of a specimen contacted with at least one first fluorophore having an emission spectrum in the range of approximately 200 nm to 1000 nm, the first image created using a first wavelength of invisible light. The processor receives a second image of a second section of the specimen, the second section adjacent to the first section and the second image created using the first wavelength of invisible light. The processor co-registers the first image and the second image. The processor creates a single-plane image of the first section using a next-image process; wherein the creating of the image includes a debluring process. The processor receives an image of a third section of the specimen created using the first wavelength of invisible light. The processor creates a 3D image of the specimen using at least three images of adjacent specimen sections.

Fluorescence Histo-Tomography (Fht) Systems And Methods

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US Patent:
20160370349, Dec 22, 2016
Filed:
Aug 31, 2016
Appl. No.:
15/253149
Inventors:
- Boston MA, US
- Marlborough MA, US
Robert William Holt - Boston MA, US
Mohammed Q. Qutaish - Medford MA, US
Marc Edward Seaman - Norwood MA, US
Mark W. Bordo - Worcester MA, US
Jacob Yost Hesterman - Newton MA, US
International Classification:
G01N 33/50
H04N 5/247
G06T 7/00
H04N 5/225
Abstract:
In one embodiment, a fluorescence histo-tomography (FHT) system is disclosed. The FHT system includes a housing, a fluorescence camera located within the housing, a white light camera located within the housing, and a fluorescence light source located within the housing. The FHT system further includes a support mount configured to support the housing within a chamber of a slicing apparatus such that the cameras and fluorescence light source are aimed towards a block face of a tissue specimen retained within the chamber.

Multi-Spectral Three Dimensional Imaging System And Method

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US Patent:
20160343131, Nov 24, 2016
Filed:
May 19, 2016
Appl. No.:
15/158928
Inventors:
- Boston MA, US
Mohammed Q. Qutaish - Medford MA, US
John W. Hoppin - Boston MA, US
Marc E. Seaman - Norwood MA, US
Jacob Y. Hesterman - Newton MA, US
International Classification:
G06T 7/00
G06T 15/00
G06T 5/00
Abstract:
Disclosed is a computer-implemented method of creating an image of a specimen including receiving a first image of a first section of a specimen created using a first wavelength of invisible light a second image of a second section of the specimen adjacent to the first section and the second image created using the first wavelength of invisible light, co-registering the first image and the second image and creating, by the processor, a single-plane image of the first section using a next-image process.

Assessment Of Labeled Probes In A Subject

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US Patent:
20160029983, Feb 4, 2016
Filed:
Mar 12, 2014
Appl. No.:
14/774577
Inventors:
- Cambridge MA, US
Jack Hoppin - Boston MA, US
Jacob Hesterman - Brighton MA, US
Assignee:
Biogen MA Inc. - Cambridge MA
International Classification:
A61B 6/00
A61K 51/10
Abstract:
Wearable apparatus and method of using same for tracking a labeled probe in a subject are disclosed.

Estimating Pharmacokinetic Parameters In Imaging

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US Patent:
20150297160, Oct 22, 2015
Filed:
Jun 7, 2013
Appl. No.:
14/405901
Inventors:
Kelly Davis Orcutt - Somerville MA, US
John Hoppin - Boston MA, US
Jacob Hesterman - Boston MA, US
Christian Lackas - Cologne, DE
- Boston MA, US
International Classification:
A61B 6/00
A61B 5/00
A61B 6/03
G06F 19/00
A61B 5/055
Abstract:
A method of estimating a parameter of physiological significance in the central nervous system (CNS) is provided. The method comprises (a) providing one or more images of the brain or cerebral spinal fluid (CSF) in a subject to whom a dose of a contrast agent (CA) has been administered; (b) determining, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the brain or CSF, thereby generating concentration data; (c) describing the time-based behavior of concentrations of CA within the brain or CSF using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters; and (d) fitting, using computer code, the pharmacokinetic model to the concentration data, varying one or more parameters, wherein the best fit estimates a parameter of physiological significance in the CNS.

Estimating Pharmacokinetic Parameters In Imaging

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US Patent:
20140321723, Oct 30, 2014
Filed:
Dec 8, 2011
Appl. No.:
13/992358
Inventors:
Kelly Davis Orcutt - Somerville MA, US
John Hoppin - Boston MA, US
Jacob Hesterman - Brighton MA, US
Christian Lackas - Cologne, DE
Assignee:
INVICRO LLC - Boston MA
International Classification:
G06T 7/00
US Classification:
382128
Abstract:
A method is provided for estimating a parameter of physiological significance. One or more images are provided of a tissue in a subject to whom a dose of a contrast agent (CA) has been administered, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the tissue is determined, thus generating concentration data. The time-based behavior of concentrations of CA within the tissue is determined using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters. Using computer code, the pharmacokinetic model is fit to the concentration data, varying one or more parameters, such that a best fit estimate of a parameter of physiological significance is provided.
Jacob Y Hesterman from Newton, MA, age ~44 Get Report