Jacob Y Cha

20210122747, Apr 29, 2021

Jun 5, 2020

16/894712

- South San Francisco CA, US
Randall L. HALCOMB - Foster City CA, US
Gustave BERGNES - Pacifica CA, US
Hui LI - Santa Clara CA, US
Lan JIANG - Foster City CA, US
Jacob CHA - San Bruno CA, US
Timothy HOM - Sunnyvale CA, US

C07D 471/04

The invention relates to compounds of formula (I):or a salt thereof, wherein R, R, R, R. X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

20210024516, Jan 28, 2021

Mar 4, 2020

16/809244

- South San Francisco CA, US
Gustave BERGNES - Pacifica CA, US
Chun CHEN - Albany CA, US
Hui LI - Santa Clara CA, US
Patrick ANDRE - Short Hills NJ, US
Randall HALCOMB - Foster City CA, US
Jacob CHA - San Bruno CA, US
Timothy HOM - Sunnyvale CA, US

C07D 471/04
A61P 1/16
A61P 9/00
A61P 17/00
A61P 13/12
A61P 1/00
A61P 11/00
C07D 213/74
C07D 233/70
C07D 233/88
C07D 241/06
C07D 241/08
C07D 263/28
C07D 265/08
C07D 277/18
C07D 279/06

The invention relates to compounds of formula (I):or a salt thereof, wherein R, A, L, and Rand n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.

20200123151, Apr 23, 2020

Jun 27, 2019

16/455490

- South San Francisco CA, US
Maureen REILLY - Burlingame CA, US
Darren FINKELSTEIN - Palo Alto CA, US
Nicole COOPER - Oakland CA, US
Christopher BAILEY - Mountain View CA, US
Jacob CHA - San Bruno CA, US

C07D 471/04
C07D 519/00

The invention relates to compounds of formula (A):or a salt thereof, wherein R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, n, and G are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αβintegrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

20190322663, Oct 24, 2019

Dec 20, 2017

16/471521

- South San Francisco CA, US
Randall L. HALCOMB - Foster City CA, US
Gustave BERGNES - Pacifica CA, US
Hui LI - Santa Clara CA, US
Lan JIANG - Foster City CA, US
Jacob CHA - San Bruno CA, US
Timothy HOM - Sunnyvale CA, US

C07D 471/04

The invention relates to compounds of formula (I): formula (I) or a salt thereof wherein R, R, R, R, X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

20180127388, May 10, 2018

Jul 25, 2017

15/658818

- Foster City CA, US
Gediminas Brizgys - Menlo Park CA, US
Jacob Y. Cha - Burlingame CA, US
Xiaowu Chen - Hillsborough CA, US
Hongyan Guo - San Mateo CA, US
Randall L. Halcomb - Foster City CA, US
Xiaochun Han - Santa Clara CA, US
Richard Huang - San Mateo CA, US
Hongtao Liu - Cupertino CA, US
Ryan McFadden - Foster City CA, US
Michael L. Mitchell - Castro Valley CA, US
Yingmei Qi - Foster City CA, US
Paul A. Roethle - Berkeley CA, US
Lianhong Xu - Palo Alto CA, US
Hong Yang - Fremont CA, US

C07D 277/82
C07D 498/04
A61K 31/428
C07D 487/04
C07D 471/04
C07D 417/14
C07D 417/10
C07D 417/04
C07D 277/68
C07D 277/66
A61K 45/06
A61K 31/553
A61K 31/551
A61K 31/5383
A61K 31/538
A61K 31/5377
A61K 31/513
A61K 31/506
A61K 31/501
A61K 31/4985
A61K 31/497
A61K 31/496
A61K 31/4741
A61K 31/4709
A61K 31/454
A61K 31/444
A61K 31/4439
A61K 31/4375
A61K 31/437
A61K 31/436
C07D 491/06

Compounds disclosed herein including compounds of formula I′:and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.

20180093984, Apr 5, 2018

Sep 7, 2017

15/698435

- Redwood City CA, US
Gustave BERGNES - Pacifica CA, US
Chun CHEN - Albany CA, US
Hui LI - Santa Clara CA, US
Patrick ANDRE - Short Hills NJ, US
Randall L. HALCOMB - Foster City CA, US
Jacob CHA - Burlingame CA, US
Timothy HOM - Sunnyvale CA, US

C07D 471/04
C07D 241/08
C07D 213/74
C07D 241/06
C07D 263/28
C07D 277/18
C07D 233/70
C07D 265/08
C07D 279/06
C07D 233/88
A61P 11/00
A61P 1/16
A61P 17/00
A61P 9/00
A61P 13/12
A61P 1/00

The invention relates to compounds of formula (I):or a salt thereof, wherein R, A, L, and Rand n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.