Inventors:
Abdul R. Khokhar - Houston TX
Robert A. Newman - Houston TX
Irwin H. Krakoff - Houston TX
Assignee:
The Board of Regents, The University of Texas System - Austin TX
International Classification:
C07F 1500
A01N 4304
A01N 5502
A61K 3128
Abstract:
The present invention comprises a water-soluble square-planar cis-platinum(II) four-coordinate complex having the formula: trans-R,R-DACH Pt(II) X. sub. 2 or trans-R,R-DACH Pt(II) Y wherein X is a monovalvent cation, two of which are present, selected from the group consisting of cyclopropanecarboxylato, shikimato, saccharatolactone, galacturonato and N,N-dimethyglycinato; wherein Y is a divalent cation selected from the group consisting of citraconato, 1,1-cyclobutanedicarboxylato, 1,1-cyclopropanedicarboxylato, isocitratolactone and Z-iminodiacetato where Z is bound to the nitrogen and is ethyl, propyl, Isopropyl, n-butyl, sec-butyl, ter-butyl, n-amyl, isoamyl or OH. In one preferred aspect the water-soluble square-planar cis-platinum(II) four-coordinate complex has the formula: trans-R,R-DACH Pt(II) X. sub. 2 wherein X is a monovalent cation.