Hossain Jahansouz Phones & Addresses
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2916 E Branham Ln, Phoenix, AZ 85042
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Half Moon Bay, CA
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Dallas, TX
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Arlington, TX
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Foster City, CA
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Fort Worth, TX
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North Wales, PA
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Alexandria, VA
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Hillsborough, CA
Publications
Us Patents
Lyophilized Anti-Fungal Compositions
View pageUS Patent:
8551942, Oct 8, 2013
Filed:
Sep 27, 2012
Appl. No.:
13/628592
Inventors:
Hossain Jahansouz - Burlingame CA, US
Assignee:
Merck Sharp & Dohme, Corp. - Rahway NJ
International Classification:
A01N 37/18
A61K 38/12
A61P 31/10
A61K 38/12
A61P 31/10
US Classification:
514 36
Abstract:
A lyophilized anti-fungal composition comprises (A) caspofungin, or a pharmaceutically acceptable salt thereof, in an effective amount; (B) one or more non-reducing sugars having a glass transition temperature T(s) of at least about 90 C. ; and (C) an acetate buffer in an amount effective to provide a pH in a range of from about 5 to about 7; wherein the weight ratio of the one or more non-reducing sugars to caspofungin is in a range of from about 1. 1:1 to about 10:1; the composition has a moisture content of about 0. 8 wt. % or less; and the composition has a glass transition temperature T(c) of at least about 55 C. The lyophilized composition has good storage stability at temperatures up to and including room temperature. The composition can be reconstituted for use in preventing or treating fungal infections.
Lyophilized Anti-Fungal Composition
View pageUS Patent:
20100137197, Jun 3, 2010
Filed:
Jun 23, 2008
Appl. No.:
12/666426
Inventors:
Sachin Mittal - Telford PA, US
Hossain Jahansouz - Foster City CA, US
Suttilug Sotthivirat - Lansdale PA, US
Hossain Jahansouz - Foster City CA, US
Suttilug Sotthivirat - Lansdale PA, US
International Classification:
A61K 38/12
US Classification:
514 9
Abstract:
A lyophilized anti-fungal composition comprises (A) caspofungin, or a pharmaceutically acceptable salt thereof, in an effective amount; (B) one or more non-reducing sugars having a glass transition temperature T(s) of at least about 90 C.; and (C) an acetate buffer in an amount effective to provide a pH in a range of from about 5 to about 7; wherein the weight ratio of the one or more non-reducing sugars to caspofungin is in a range of from about 1.1:1 to about 10:1; the composition has a moisture content of about 0.8 wt. % or less; and the composition has a glass transition temperature T(c) of at least about 55 C. The lyophilized composition has good storage stability at temperatures up to and including room temperature. The composition can be reconstituted for use in preventing or treating fungal infections.