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Horacio G Nastri

from West Chester, PA
Age ~62
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Also known as:
Horacio G Mastri, Heratio Nastri
Phone and address:
846 Penns Way, West Chester, PA 19382
(781) 444-6068
Related to:
Shari C Nastri, 54Christen L Nastri, 40Nicolas Nastri, 30Sofia Nastri, 26
Connected to:
Ashley B Nastri, 49Frederick D Nastri, 78Lera L Nastri, 63Christine C Nastro, 57Paul J Nastro, 67Thomas P Nastro, 38Darrel H Nastrom, 83Dennis H Nastrom, 83Nancy J Nastruz, 58Jennifer H Nastu, 55

Horacio Nastri Phones & Addresses

  • 846 Penns Way, West Chester, PA 19382 (781) 444-6068
  • Wilmington, DE
  • Armonk, NY
  • 18 Pennsylvania Ave, Newton Upper Falls, MA 02464 (617) 641-9466
  • Newton, MA
  • 1082 Greendale Ave, Needham, MA 02492 (781) 444-6068
  • Waltham, MA
  • Shrewsbury, MA
  • Newton U F, MA
  • 66 Round Hill Rd, Armonk, NY 10504 (781) 444-6068

Work

Company: Pfizer Nov 2011 Address: Greater New York City Area Position: Director biotherapeutics, cti new york

Education

Degree: Ph.D School / High School: Universidad de Buenos Aires 1986 to 1991 Specialities: Chemistry

Skills

Antibodies • Protein Chemistry • Molecular Biology • Biotechnology • Drug Discovery • Protein Expression • Life Sciences • Assay Development • Monoclonal Antibodies • Biopharmaceuticals • Protein Engineering • Drug Development • Biochemistry • Validation • Cell • Phage Display • Dna • Pharmaceutical Industry • Immunology • Elisa • Biomarker Discovery • Lifesciences • Automation • Single B Cell Cloning • Bioinformatics • Antibody Discovery • Technology Development • Cloning • Antibody Screening

Languages

English • Spanish

Industries

Pharmaceuticals

Resumes

Resumes

Horacio Nastri Photo 1

Executive Director Antibody Discovery

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Location:
200 Powder Mill Rd, Wilmington, DE 19803
Industry:
Pharmaceuticals
Work:
Pfizer - Greater New York City Area since Nov 2011
Director Biotherapeutics, CTI New York
EMD Serono 2003 - Nov 2011
Head of Antibody Technologies
Dyax 2001 - 2002
Associate Director
Dyax 1999 - 2002
Senior Scientist
New England Biolabs 1995 - 1999
Postodoctoral Fellow
Education:
Universidad de Buenos Aires 1986 - 1991
Ph.D, Chemistry Universidad de Buenos Aires 1980 - 1986
BS-Chemistry
Skills:
Antibodies
Protein Chemistry
Molecular Biology
Biotechnology
Drug Discovery
Protein Expression
Life Sciences
Assay Development
Monoclonal Antibodies
Biopharmaceuticals
Protein Engineering
Drug Development
Biochemistry
Validation
Cell
Phage Display
Dna
Pharmaceutical Industry
Immunology
Elisa
Biomarker Discovery
Lifesciences
Automation
Single B Cell Cloning
Bioinformatics
Antibody Discovery
Technology Development
Cloning
Antibody Screening
Languages:
English
Spanish

Publications

Us Patents

Methods Of Constructing Libraries Comprising Displayed And/Or Expressed Members Of A Diverse Family Of Peptides, Polypeptides Or Proteins And The Novel Libraries

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US Patent:
8288322, Oct 16, 2012
Filed:
Oct 25, 2001
Appl. No.:
10/045674
Inventors:
Robert C. Ladner - Ijamsville MD, US
Edward H. Cohen - Belmont MA, US
Horacio G. Nastri - Newton MA, US
Kristin L. Rookey - Revere MA, US
Rene Hoet - Maastricht, NL
Hendricus Renerus Jacobus Mattheus Hoogenboom - Maastricht, NL
Assignee:
Dyax Corp. - Burlington MA
International Classification:
C12Q 1/68
C12P 19/34
US Classification:
506 18, 435 61, 435 618, 435 912
Abstract:
A library containing a collection of genetic packages that display a member of a diverse family of peptides, polypeptides or proteins and that collectively display at least a portion of the family, the displayed peptides, polypeptides or proteins being encoded by DNA sequences containing sequences encoding a heavy chain CDR region is described.

Novel Methods Of Constructing Libraries Of Genetic Packages That Collectively Display The Members Of A Diverse Family Of Peptides, Polypeptides Or Proteins

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US Patent:
20040029113, Feb 12, 2004
Filed:
Apr 17, 2001
Appl. No.:
09/837306
Inventors:
Robert Ladner - Ijamsville MD, US
Edward Cohen - Belmont MA, US
Horacio Nastri - Newton MA, US
Kristin Rookey - Revere MA, US
Rene Hoet - Maastricht, NL
International Classification:
C12Q001/68
C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
The present invention relates to constructing libraries of genetic packages that display a member of a diverse family of peptides, polypeptides or proteins and collectively display at least a portion of the diversity of the family. In a preferred embodiment, the displayed polypeptides are human Fabs. More specifically, the invention is directed to the methods of cleaving single-stranded nucleic acids at chosen locations, the cleaved nucleic acids encoding, at least in part, the peptides, polypeptides or proteins displayed on the genetic packages of the libraries of the invention. In a preferred embodiment, the genetic packages are filamentous phage or phagemids. The present invention further relates to methods of screening the libraries of genetic packages that display useful peptides, polypeptides and proteins and to the peptides, polypeptides and proteins identified by such screening.

Novel Methods Of Constructing Libraries Of Genetic Packages That Collectively Display The Members Of A Diverse Family Of Peptides, Polypeptides Or Proteins

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US Patent:
20060166252, Jul 27, 2006
Filed:
Feb 28, 2006
Appl. No.:
11/365556
Inventors:
Robert Ladner - Ijamsville MD, US
Edward Cohen - Belmont MA, US
Horacio Nastri - Newton MA, US
Kristin Rookey - Revere MA, US
Rene Hoet - Maastricht, NL
International Classification:
C40B 40/08
C40B 40/10
US Classification:
435006000
Abstract:
Methods useful in constructing libraries that collectively display members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

Novel Methods Of Constructing Libraries Comprising Displayed And/Or Expressed Members Of A Diverse Family Of Peptides, Polypeptides Or Proteins And The Novel Libraries

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US Patent:
20130040861, Feb 14, 2013
Filed:
May 4, 2012
Appl. No.:
13/464047
Inventors:
Robert C. Ladner - Ijamsville MD, US
Edward H. Cohen - Belmont MA, US
Horacio G. Nastri - Newton MA, US
Kristin L. Rookey - Revere MA, US
Rene Hoet - Maastricht, NL
Hendricus Renerus Jacobus Mattheus Hoogenboom - Maastricht, NL
Assignee:
DYAX CORP. - Burlington MA
International Classification:
C40B 50/06
C40B 40/10
C12N 15/63
C12P 19/34
US Classification:
506 18, 435 9153, 506 26, 4353201, 435 912
Abstract:
Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods are disclose. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens are also disclosed.

Multispecific Binding Moieties Comprising Novel Pd-1 Binding Domains

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US Patent:
20220363761, Nov 17, 2022
Filed:
Mar 30, 2022
Appl. No.:
17/708901
Inventors:
- Utrecht, NL
- Wilmington DE, US
Horacio G. NASTRI - Wilmington DE, US
Shaun M. STEWART - Wilmington DE, US
International Classification:
C07K 16/28
A61P 35/00
Abstract:
The present disclosure relates to multispecific binding moieties comprising novel PD-1 binding domains that have a higher binding affinity for human PD-1 than a reference PD-1 binding domain. Such multispecific binding moieties further provide a comparable, or equal or higher, potency in blocking ligand binding to human PD-1 than a reference PD-1 antibody. The present disclosure in particular relates to multispecific binding moieties comprising a novel PD-1 binding domain and a LAG-3 binding domain. Also provided is a method for treating a disease, in particular a disease associated with a suppressed immune system, such as cancer, with a multispecific binding moiety of the present disclosure. The present disclosure further relates to a vector and cell comprising nucleic acids encoding a novel PD-1 binding domain and a LAG-3 binding domain.

Combination Therapy Comprising A2A/A2B Inhibitors, Pd-1/Pd-L1 Inhibitors, And Anti-Cd73 Antibodies

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US Patent:
20220233529, Jul 28, 2022
Filed:
Dec 29, 2021
Appl. No.:
17/564549
Inventors:
- Wilmington DE, US
Juan Carlos Almagro - Cambridge MA, US
Rebecca A. Buonpane - Wilmington DE, US
Peter Niels Carlsen - Claymont DE, US
Taisheng Huang - Wilmington DE, US
Yong Li - Newark DE, US
Horacio G. Nastri - West Chester PA, US
Chao Qi - Newark DE, US
Shaun M. Stewart - Chadds Ford PA, US
Xiaozhao Wang - Mt. Laurel NJ, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
Jing Zhou - Boxborough MA, US
Wenyu Zhu - Media PA, US
International Classification:
A61K 31/501
A61P 35/00
A61K 39/395
C07K 16/28
Abstract:
Disclosed are combination therapies comprising administration of a CD73 inhibitor, an adenosine A2A or A2B receptor inhibitor, and a PD-1/PD-L1 inhibitor. The disclosed combination therapies are useful in the treatment of diseases related to the activity of adenosine receptors and/or CD73 and/or PD-1/PD-L1 including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases. Anti-CD73 antibodies, PD-1/PD-L1 inhibitors, and A2A/A2B inhibitors are also disclosed.

Combination Therapy Comprising A2A/A2B And Pd-1/Pd-L1 Inhibitors

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US Patent:
20210205311, Jul 8, 2021
Filed:
Dec 30, 2020
Appl. No.:
17/138485
Inventors:
- Wilmington DE, US
Juan Carlos Almagro - Cambridge MA, US
Rebecca A. Buonpane - Wilmington DE, US
Peter Niels Carlsen - Claymont DE, US
Taisheng Huang - Wilmington DE, US
Yong Li - Newark DE, US
Luping Lin - Garnet Valley PA, US
Horacio G. Nastri - West Chester PA, US
Chao Qi - Newark DE, US
Shaun M. Stewart - Chadds Ford PA, US
Pramod Unnikrishnan Thekkat - Chadds Ford PA, US
Xiaozhao Wang - Mt. Laurel NJ, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
Jing Zhou - Boxborough MA, US
Wenyu Zhu - Media PA, US
International Classification:
A61K 31/519
A61K 39/395
A61P 35/00
A61K 31/501
A61K 31/506
A61K 31/4985
A61K 31/444
Abstract:
The present application provides methods of treating cancer using a combination of an inhibitor of A2A and/or A2B and an inhibitor of PD-1 and/or PD-L1.

Novel Methods Of Constructing Libraries Comprising Displayed And/Or Expressed Members Of A Diverse Family Of Peptides, Polypeptides Or Proteins And The Novel Libraries

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US Patent:
20210087256, Mar 25, 2021
Filed:
Aug 4, 2020
Appl. No.:
16/984655
Inventors:
- Lexington MA, US
Edward H. Cohen - Belmont MA, US
Horacio G. Nastri - Newton MA, US
Kristin L. Rookey - Lebanon NH, US
Rene Hoet - Maastricht, NL
Hendricus Renerus Jacobus Mattheus Hoogenboom - Maastricht, NL
Assignee:
Dyax Corp. - Lexington MA
International Classification:
C07K 16/00
C12N 15/10
C12N 15/66
C40B 40/02
Abstract:
Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
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Horacio G Nastri from West Chester, PA, age ~62 Get Report