US Patent:
20070275918, Nov 29, 2007
Inventors:
Hiroaki Kiyokawa - Chicago IL, US
Xianghong Zou - Columbus OH, US
Assignee:
The Board of Trustees of the University of Illinois - Urbana IL
International Classification:
A61K 31/7105
C07H 21/04
C12N 15/11
US Classification:
514044000, 435375000, 536023100
Abstract:
The invention provides methods of inhibiting growth of tumor cells comprising contacting the cells with a Cdk4 inhibitor. The invention also provides methods of treating patients having, suspected of having, or at a high risk for developing, a cancer, comprising treatment with a Cdk4 inhibitor. The invention also relates to pharmaceutical compositions for treating such patients, wherein the pharmaceutical compositions comprise a Cdk4 inhibitor. The invention further relates to Cdk4 siRNA molecules capable of inhibiting Cdk4 expression or activity.