Inventors:
Steven D. Salhanick - Andover MA, US
Hilton A. Salhanick - Brookline MA, US
International Classification:
A61K 31/7076
A61K 31/7072
A61P 1/16
Abstract:
Disclosed are compositions and methods of treatment with uridine-based and phosphoadenosine-based cofactors for the prevention and treatment of toxicity associated with compounds such as acetaminophen, which undergo Phase II glucuronidation and sulfonation in the liver. Uridine diphosphoglucose, phosphoadenosine-phosphosulfate, and their derivatives can be administered exogenously either to prevent their depletion in the liver during treatment with acetaminophen, or to replace depleted substrates of UDPGA-transferase or PAPS-transferase in order to treat an individual after a toxic dose of acetaminophen has been ingested.