Inventors:
Kuo-Hsiung Lee - Chapel Hill NC
Junko Ishida - Tokyo, JP
Hironari Ohtsu - Chapel Hill NC
Hideji Itokawa - Chapel Hill NC
Chawnshang Chang - Pittsford NY
Charles C-Y. Shih - Solana Beach CA
Assignee:
University of North Carolina at Chapel Hill - Chapel Hill NC
International Classification:
C07C 6976
US Classification:
560 53, 568325, 514541, 514646
Abstract:
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.