Inventors:
Melwyn Abreo - Jamul CA, US
Daniel F. Harvey - San Diego CA, US
Heinz W. Gschwend - Santa Rosa CA, US
Wenbao Li - San Diego CA, US
Chi Tu - San Diego CA, US
Rajender Kamboj - Burnaby, CA
Michael D. Winther - Vancouver, CA
Vishnumurthy Kodumuru - Burnaby, CA
Cindy J. Hudson - Buena Park CA, US
Mikhail A. Kondratenko - San Diego CA, US
Shifeng Liu - Port Coquitlam, CA
Vandna Raina - Vancouver, CA
Serguei Sviridov - Burnaby, CA
Zaihui Zhang - Vancouver, CA
Mehran Seid Bagherzadeh - North Vancouver, CA
Shaoyi Sun - Vancouver, CA
Assignee:
Xenon Pharmaceuticals Inc. - Burnaby, British Columbia
International Classification:
A61K 31/497
C07D 241/04
C07D 295/00
Abstract:
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is —O—, —N(R1)—, C(O), S(O)t; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1), C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)—, C(O)O—, S(O)2—, S(O)2N(R1)— or C(R11)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7, R8, R8, R9, R9, R10 and R10are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.