Inventors:
Michael S. Roberts - Walkersville MD, US
Robert M. Lorence - Bethesda MD, US
William S. Groene - New Market MD, US
Harvey Rabin - Rockville MD, US
Reid W. von Borstel - Potomac MD, US
Assignee:
Wellstat Biologics Corporation - Gaithersburg MD
International Classification:
A61K 48/00
C12N 7/01
Abstract:
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.