US Patent:
20070167526, Jul 19, 2007
Inventors:
Xiaoming Zhang - Sunnyvale CA, US
Muralitharan Kengatharan - Menlo Park CA, US
John Cooke - Palo Alto CA, US
Harun Takruri - Newport Beach CA, US
International Classification:
A61K 31/137
Abstract:
Provided are methods, pharmaceutical formulations and kits thereof for the treatment and/or prevention of conditions mediated by neovascularization, abnormal angiogenesis, vascular permeability, or combinations thereof, of posterior and/or anterior tissues and fluids of the eye, including conditions associated with proliferative retinopathies, for example, diabetic retinopathy, age-related maculopathy, retinopathy of prematurity, retinopathy associated with macular edema, or retinopathy associated with sickle cell disease, using the topical administration of mecamylamine or a pharmaceutically acceptable salt thereof to the eye. Methods of preparing the pharmaceutical formulations are also provided.
