US Patent:
20040138242, Jul 15, 2004
Inventors:
Donghui Cui - Newtown PA, US
Margaret Davis - Redmond WA, US
Michael Dunn - Cambridge MA, US
Ben Evans - Lansdale PA, US
Hanumath Kari - Hatfield PA, US
Bharat Lagu - Maywood NJ, US
Dhanapalan Nagarathnam - Bethany CT, US
Kamlesh Vyas - North Wales PA, US
Kanyin Zhang - San Diego CA, US
International Classification:
A61K031/513
C07D239/02
Abstract:
This invention is directed to dihydropyrimidines which are selective antagonists for human receptors. This invention is also related to uses of these compounds for relaxing lower urinary tract tissue, treating benign prostatic hyperplasia and for the treatment of any disease where the antagonism of the receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.