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Gopalan Soman

from Frederick, MD
Age ~76
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Also known as:
Gopal Soman, Soman Gopalan
Phone and address:
146 Harpers Way, Frederick, MD 21702
(301) 620-2194
Related to:
Soman Arya, 43Neela R Soman, 67
Connected to:
Drew C Soman, 40Jack Soman, 81Lakshmi Soman, 44Nikita S Soman, 36Prachi Soman, 45Tejas N Soman, 28Trisha A Soman, 44Maria G Somana, 36Aparnaa Somanathan, 50Kavitha Somanath, 50

Gopalan Soman Phones & Addresses

  • 146 Harpers Way, Frederick, MD 21702 (301) 620-2194 (301) 668-7273
  • 581 Lancaster Pl, Frederick, MD 21703 (301) 668-7273
  • 61 Lexington St, Belmont, MA 02478 (617) 484-8618 (781) 647-5116
  • Cambridge, MA

Publications

Us Patents

Stabilization Of Helicobacter Urease

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US Patent:
6709851, Mar 23, 2004
Filed:
Jun 23, 1999
Appl. No.:
09/338920
Inventors:
Gopalan Soman - Belmont MA
Thomas P. Monath - Harvard MA
Assignee:
OraVax-Merieux Co. - Cambridge MA
International Classification:
C12N 999
US Classification:
435227, 435184, 435188, 435228, 514 2, 530350, 530402, 530408, 530409
Abstract:
The invention provides methods for stabilizing recombinant Helicobacter urease by genetically modifying a urease amino acid. The stabilized urease is prevented from the molecular aggregation or activation (e. g. , in vitro activation) characteristic of untreated urease.

Multimeric, Recombinant Urease Vaccine

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US Patent:
58372407, Nov 17, 1998
Filed:
Aug 26, 1997
Appl. No.:
8/920095
Inventors:
Cynthia K. Lee - Needham MA
Thomas P. Monath - Harvard MA
Samuel K. Ackerman - Weston MA
William D. Thomas - Winchester MA
Gopalan Soman - Belmont MA
Harold Kleanthous - Allston MA
Richard A. Weltzin - Lunenburg MA
Jacques Pappo - Newton MA
Thomas Ermak - Brookline MA
Farshad Guirakhoo - Melrose MA
Hitesh Bhagat - Framingham MA
Ilene Sussman - Newton MA
Assignee:
OraVax-Merieux Co. - Cambridge MA
International Classification:
A61K 3846
A61K 3902
A61K 39106
US Classification:
424 946
Abstract:
Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.

Method For Preventing The Activation Of Inactive, Recombinant Helicobacter Pylori Apourease

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US Patent:
59856319, Nov 16, 1999
Filed:
Sep 12, 1997
Appl. No.:
8/928081
Inventors:
Gopalan Soman - Belmont MA
William D. Thomas - Somerville MA
Thomas P. Monath - Harvard MA
Assignee:
OraVax-Merieux Co. - Cambridge MA
International Classification:
C12N 999
C12N 996
C12N 980
A01N 3718
C07K 100
US Classification:
435184
Abstract:
A method for preventing the activation of inactive, recombinant Helicobacter pylori apourease is presented. The method comprises contacting the apourease with a compound that modifies a sulfhydryl or lysyl residue of the urease. The covalently modified apourease is prevented from molecular aggregation.
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Gopalan Soman from Frederick, MD, age ~76 Get Report