Inventors:
Glenn D. Prestwich - Salt Lake City UT, US
Xiao Zheng Shu - Salt Lake City UT, US
Yanchun Liu - Franklin TN, US
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
A01N 43/04
A01N 25/00
A61K 31/715
A61K 31/727
A61K 47/00
A61K 9/14
A61K 9/50
C07H 5/04
C07H 5/06
C08B 37/00
C08B 37/10
US Classification:
514 54, 514 56, 514777, 536 187, 536 21, 424488, 424499
Abstract:
Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide-reactive group and/or aminooxy-reactive group, and methods of making and using thereof for scar-free wound healing, for delivering bioactive agents or living cells, for preventing adhesion after a surgical procedure or for bone and cartilage repair. The macromolecule can be an oligonucleotide, a necleic acid, a polypeptide, a lipid, a glycoprotein, a glycolipid, a polysaccharide, a protein or a synthetic polymer, preferably a glycosaminoglycan like hyaluronan.