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Gjalt W Huisman

from Redwood City, CA
Age ~61
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Also known as:
Gjalt S Huisman, Gial W Huisman, Olsman K Gjalt, T Huisman
Phone and address:
2682 Eaton Ave, Redwood City, CA 94062
(650) 257-3958
Related to:
Robert R Huisman, 71
Connected to:
Anna M Huisman, 30Avia J Huisman, 47Chloe E Huisman, 36David R Huismann, 37Gijs Huisman, 41Jan A Huisman, 61Janny S Huisman, 71Kyle D Huisman, 39Larry J Huisman, 64Lawrence L Huisman, 71

Gjalt Huisman Phones & Addresses

  • 2682 Eaton Ave, Redwood City, CA 94062 (650) 257-3958
  • 2211 Howard Ave, San Carlos, CA 94070
  • 52 Salem St, Boston, MA 02113 (617) 367-0253
  • 152 Salem St, Boston, MA 02113
  • Chestnut Hill, MA
  • Medford, MA
  • 35 Harold St, Somerville, MA 02143
  • Newburyport, MA
  • 2682 Eaton Ave, Redwood City, CA 94062

Work

Company: Codexis Jan 2013 Address: San Francisco Bay Area Position: Vice president, pharmaceutical r&d

Education

Degree: Post Doctoral Fellow School / High School: Harvard Medical School 1992 to 1994 Specialities: Microbial Physiology of non-growing E. coli

Skills

Biotechnology • R&D • Analytical Chemistry • Chemistry • Technology Transfer • Life Sciences • Molecular Biology • Microbiology • High Throughput Screening • Drug Discovery • Protein Chemistry • Lifesciences • Biochemistry • Fermentation • Pharmaceutical Industry • Biopharmaceuticals • Enzymes • Commercialization • Biocatalysis • Organic Chemistry • Medicinal Chemistry • Laboratory • Innovation Development • Hplc • Program Management • Enzyme Engineering • Protein Engineering • Enzyme Replacement Therapy • Biofuels • Ip

Industries

Biotechnology

Resumes

Resumes

Gjalt Huisman Photo 1

Senior Vp, Strategic Development

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Location:
Berkeley, CA
Industry:
Biotechnology
Work:
Codexis - San Francisco Bay Area since Jan 2013
Vice President, Pharmaceutical R&D
Codexis - San Francisco Bay Area Jan 2010 - Dec 2012
Vice President, Product Planning, Pharmaceutical Chemicals
Codexis - San Francisco Bay Area 2002 - Dec 2009
Director R&D
Maxygen - San Francisco Bay Area 1998 - 2001
Director R&D
Metabolix - Greater Boston Area 1994 - 1998
Group Leader
Education:
Harvard Medical School 1992 - 1994
Post Doctoral Fellow, Microbial Physiology of non-growing E. coli University of Groningen 1981 - 1991
PhD, Chemistry Stedelijk Gymnasium Leeuwarden 1975 - 1981
Skills:
Biotechnology
R&D
Analytical Chemistry
Chemistry
Technology Transfer
Life Sciences
Molecular Biology
Microbiology
High Throughput Screening
Drug Discovery
Protein Chemistry
Lifesciences
Biochemistry
Fermentation
Pharmaceutical Industry
Biopharmaceuticals
Enzymes
Commercialization
Biocatalysis
Organic Chemistry
Medicinal Chemistry
Laboratory
Innovation Development
Hplc
Program Management
Enzyme Engineering
Protein Engineering
Enzyme Replacement Therapy
Biofuels
Ip

Business Records

Name / Title
Company / Classification
Phones & Addresses
Gjalt Huisman
Product Manager
Codexis, Inc.
Biotechnology · Commercial Physical Research · Research and Development in the Physical, Engineering, and L
200 Penobscot Dr, Redwood City, CA 94063
200 Penobscott Dr, Redwood City, CA 94062
(650) 421-8100, (650) 421-8102, (650) 980-5600
Gjalt Huisman
Manager
MAXYGEN, INC
Mfg of Pharmaceutical Preparations and Biotechnological Research Services · Pharmaceutical Preparations & Biotechnological Research · Pharmaceutical Preparations and Biotechnological Research · Research and Development in the Physical, Engineering, and L · Pharmaceutical Preparation Manufacturing · Research & Development in Biotechnology · Biotechnology Products & Servi
515 Galveston Dr, Redwood City, CA 94063
301 Galveston Dr, Redwood City, CA 94063
(650) 298-5300, (650) 298-5399, (650) 298-5885, (650) 364-2715

Publications

Us Patents

Transgenic Microbial Polyhydroxyalkanoate Producers

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US Patent:
6593116, Jul 15, 2003
Filed:
Aug 17, 1999
Appl. No.:
09/375975
Inventors:
Gjalt W. Huisman - San Carlos CA
Oliver P. Peoples - Arlington MA
Frank A. Skraly - Boston MA
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C12P 762
US Classification:
435135, 435143, 435146, 435183, 435190, 435191, 435193, 435232, 435375, 4352523, 4353201, 435829, 435831, 435877, 536 232
Abstract:
Transgenic microbial strains are provided which contain the genes required for PHA formation integrated on the chromosome. The strains are advantageous in PHA production processes, because (1) no plasmids need to be maintained, generally obviating the required use of antibiotics or other stabilizing pressures, and (2) no plasmid loss occurs, thereby stabilizing the number of gene copies per cell throughout the fermentation process, resulting in homogeneous PHA product formation throughout the production process. Genes are integrated using standard techniques, preferably transposon mutagenesis. In a preferred embodiment wherein mutiple genes are incorporated, these are incorporated as an operon. Sequences are used to stabilize mRNA, to induce expression as a function of culture conditions (such as phosphate concentration), temperature, and stress, and to aid in selection, through the incorporation of selection markers such as markers conferring antibiotic resistance.

Biological Systems For Manufacture Of Polyhydroxyalkanoate Polymers Containing 4-Hydroxyacids

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US Patent:
6689589, Feb 10, 2004
Filed:
Nov 9, 2001
Appl. No.:
10/006915
Inventors:
Gjalt W. Huisman - San Carlos CA
Frank Skraly - Somerville MA
David P. Martin - Arlington MA
Oliver P. Peoples - Arlington MA
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C12P 762
US Classification:
435135, 435490, 43525233, 4353201
Abstract:
The gene encoding a 4-hydroxybutyryl-Co A transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, including both bacteria and plants. The new pathways provide means for producing 4HB containing PHAs from cheap carbon sources such as sugars and fatty acids, in high yields, which are stable. Useful strains are obtaining by screening strains having integrated into their genomes a gene encoding a 4HB-CoA transferase and/or PHA synthase, for polymer production. Processes for polymer production use recombinant systems that can utilize cheap substrates. Systems are provided which can utilize amino acid degradation pathways, -ketoglutarate, or succinate as substrate.

Modified Starch Metabolism Enzymes And Encoding Genes For Improvement And Optimization Of Plant Phenotypes

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US Patent:
6703240, Mar 9, 2004
Filed:
Apr 12, 2000
Appl. No.:
09/547844
Inventors:
Willem P. C. Stemmer - Los Gatos CA
Sun Ai Raillard - Mountain View CA
Gjalt Huisman - San Carlos CA
Assignee:
Maxygar, Inc. - Redwood City CA
International Classification:
C12N 1500
US Classification:
435440, 435 6, 435 912, 536 231, 536 243
Abstract:
The invention provides methods for generating, identifying, and selecting polynucleotides encoding novel starch metabolizing enzymes (NSME), NSME-encoding polynucleotides, compositions of recombinant shuffled NSME protein, plant cells and microbes containing a shuffled NSME polynucleotide in expressible form, plants containing a shuffled NSME polynucleotide in expressible form, novel starch compositions produced by plants and cells, uses of such plants, cells, and starch compositions.

Transgenic Microbial Polyhydroxyalkanoate Producers

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US Patent:
6913911, Jul 5, 2005
Filed:
Jun 13, 2003
Appl. No.:
10/461069
Inventors:
Gjalt W. Huisman - San Carlos CA, US
Oliver P. Peoples - Arlington MA, US
Frank A. Skraly - Somerville MA, US
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C12P007/62
C12N001/20
C12N015/00
C07H021/04
US Classification:
435135, 435143, 435146, 435190, 435191, 435193, 435232, 435375, 4352523, 4353201, 435829, 435831, 435877, 536 232
Abstract:
Transgenic microbial strains are provided which contain the genes required for PHA formation integrated on the chromosome. The strains are advantageous in PHA production processes, because (1) no plasmids need to be maintained, generally obviating the required use of antibiotics or other stabilizing pressures, and (2) no plasmid loss occurs, thereby stabilizing the number of gene copies per cell throughout the fermentation process, resulting in homogeneous PHA product formation throughout the production process. Genes are integrated using standard techniques, preferably transposon mutagenesis. In a preferred embodiment wherein mutiple genes are incorporated, these are incorporated as an operon. Sequences are used to stabilize mRNA, to induce expression as a function of culture conditions (such as phosphate concentration), temperature, and stress, and to aid in selection, through the incorporation of selection markers such as markers conferring antibiotic resistance.

Biological Systems For Manufacture Of Polyhydroxyalkanoate Polymers Containing 4-Hydroxyacids

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US Patent:
7081357, Jul 25, 2006
Filed:
Feb 6, 2004
Appl. No.:
10/773916
Inventors:
Gjalt W. Huisman - San Carlos CA, US
Frank Skraly - Somerville MA, US
David P. Martin - Arlington MA, US
Oliver P. Peoples - Arlington MA, US
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C12P 7/62
C12N 15/53
C12N 15/54
US Classification:
435135, 435410, 435468, 43532011
Abstract:
The gene encoding a 4-hydroxybutyryl-CoA transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, including both bacteria and plants. The new pathways provide means for producing 4HB containing PHAs from cheap carbon sources such as sugars and fatty acids, in high yields, which are stable. Useful strains are obtaining by screening strains having integrated into their genomes a gene encoding a 4HB-CoA transferase and/or PHA synthase, for polymer production. Processes for polymer production use recombinant systems that can utilize cheap substrates. Systems are provided which can utilize amino acid degradation pathways, α-ketoglutarate, or succinate as substrate.

Enzymatic Processes For The Production Of 4-Substituted 3-Hydroxybutyric Acid Derivatives

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US Patent:
7125693, Oct 24, 2006
Filed:
Aug 11, 2003
Appl. No.:
10/639159
Inventors:
S. Christopher Davis - San Francisco CA, US
John H. Grate - Los Altos CA, US
David R. Gray - Walnut Creek CA, US
John M. Gruber - Mountain View CA, US
Gjalt W. Huisman - San Carlos CA, US
Steven K. Ma - Foster City CA, US
Lisa M. Newman - Redwood City CA, US
Roger Sheldon - Rijswijk, NL
Li A Wang - Palo Alto CA, US
Assignee:
Codexis, Inc. - Redwood City CA
International Classification:
C12P 13/00
US Classification:
435128
Abstract:
The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives.

Enzymatic Processes For The Production Of 4-Substituted 3-Hydroxybutyric Acid Derivatives And Vicinal Cyano, Hydroxy Substituted Carboxylic Acid Esters

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US Patent:
7132267, Nov 7, 2006
Filed:
Feb 18, 2004
Appl. No.:
10/782258
Inventors:
S. Christopher Davis - San Francisco CA, US
John H. Grate - Los Altos CA, US
David R. Gray - Walnut Creek CA, US
John M. Gruber - Mountain View CA, US
Gjalt W. Huisman - San Carlos CA, US
Steven K. Ma - Foster City CA, US
Lisa M. Newman - Redwood City CA, US
Roger Sheldon - Rijswijk, NL
Li A Wang - Newbury Park CA, US
Assignee:
Codexis, Inc. - Redwood City CA
International Classification:
C12P 13/00
US Classification:
435128
Abstract:
The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.

Evolution Of Whole Cells And Organisms By Recursive Sequence Recombination

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US Patent:
7148054, Dec 12, 2006
Filed:
Jul 11, 2002
Appl. No.:
10/194686
Inventors:
Stephen delCardayre - Belmont CA, US
Matthew Tobin - San Jose CA, US
Willem P. C. Stemmer - Los Gatos CA, US
Jon E. Ness - Sunnyvale CA, US
Jeremy Minshull - Menlo Park CA, US
Phillip Patten - Menlo Park CA, US
Linda A. Castle - Mountain View CA, US
Claus M. Krebber - Mountain View CA, US
Steve Bass - Hillsborough CA, US
Tony Cox - Mountain View CA, US
Gjalt Huisman - San Carlos CA, US
Ling Yuan - El Marcero CA, US
Joseph A. Affholter - Saratoga CA, US
Assignee:
Maxygen, Inc. - Redwood City CA
International Classification:
C12N 1/16
C12N 1/18
US Classification:
4352542, 43525421
Abstract:
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
Control profile
Gjalt W Huisman from Redwood City, CA, age ~61 Get Report