Inventors:
Ann M. Ranger - Northborough MA, US
Ellen Garber - Cambridge MA, US
Justin A. Caravella - Cambridge MA, US
Alexey A. Lugovskoy - Woburn MA, US
Joseph Arndt - Peabody MA, US
Frederick R. Taylor - Milton MA, US
Giovanna Antognetti - Foxboro MA, US
Eric Day - Cambridge MA, US
Assignee:
BIOGEN IDEC MA INC. - Cambridge MA
International Classification:
A61K 39/395
C12N 15/13
C12N 15/63
C12N 1/21
C12N 1/19
C12N 5/10
C12P 21/00
A61P 29/00
A61P 19/02
A61P 25/00
A61P 17/06
A61P 3/10
A61P 9/10
A61P 35/00
C07K 16/24
US Classification:
4241581, 5303892, 5303873, 536 2353, 4353201, 4352523, 43525233, 43525231, 4352542, 43525421, 43525423, 435335, 435 696
Abstract:
The instant invention is based, at least in part on the identification of a new class of antibodies that result, e.g., in improved LT blocking capabilities. Methods of making the subject binding molecules and methods of using the binding molecules of the invention to antagonize LTβR signaling are also provided.