US Patent:
20080166352, Jul 10, 2008
Inventors:
Gerald Siu - Santa Monica CA, US
Wenyan Shen - Thousand Oaks CA, US
Steven Kiyoshi Yoshinaga - Thousand Oaks CA, US
Haichun Huang - Fremont CA, US
Assignee:
AMGEN INC. - Thousand Oaks CA
International Classification:
A61K 39/395
C07K 16/00
G01N 33/53
C07H 21/00
C12N 1/00
C07K 7/06
C07K 7/08
A61K 38/08
A61K 38/10
A61P 37/00
A61P 29/00
US Classification:
4241391, 5303871, 5303873, 436501, 536 2353, 435243, 530330, 530329, 530328, 530327, 530326, 514 17, 514 16, 514 15, 514 14, 514 13, 536 235
Abstract:
This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RP1 antibodies Methods of detecting the amount of B7RP1 in a sample using anti-B7RP1 antibodies are also provided.