Inventors:
Amy Mae Bunker - Middletown CT
Xue-Min Cheng - Ann Arbor MI
Annette Marian Doherty - Paris, FR
Jeremy John Edmunds - Ypsilanti MI
Gerald David Kanter - West Bloomfield MI
Chitase Lee - Ann Arbor MI
Joseph Thomas Repine - Ann Arbor MI
Richard William Skeean - Ann Arbor MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
C07D27902
Abstract:
The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula I The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.