Inventors:
George K. Abruzzo - Clark NJ, US
Kenneth F. Bartizal - Hampton NJ, US
Amy M. Flattery Feighner - Holmdel NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 38/00
A61K 31/70
A61K 31/45
US Classification:
514 11, 514 31, 514394, 514395
Abstract:
There is described antifungal combination therapy comprising the use of known antifungal agents such as the azoles or polyenes in combination with a pneumocandin derivative antifungal agent. More particularly, the invention relates to antifungal combination therapy comprising the use of azoles such as fluconazole, voriconazole, itraconazole, ketoconazole, miconazole, ER 30346, SCH 56592; polyenes such as amphotericin B, nystatin or liposomal and lipid forms thereof such as Abelcet, AmBisome and Amphocil; purine or pyrimidine nucleotide inhibitors such as flucytosine; or polyoxins such as nikkomycins, in particular nikkomycin Z or other chitin inhibitors, elongation factor inhibitors such as sordarin and analogs thereof, mannan inhibitors such as predamycin, bactericidal/permeability-inducing (BPI) protein products such as XMP. 97 or XMP. 127 or complex carbohydrate antifungal agents such as CAN-296 in combination with a pneumocandin derivative as described herein.