Geoff R Facer

8440093, May 14, 2013

Oct 11, 2006

11/546939

Hany Nassef - San Mateo CA, US
Geoff Facer - San Francisco CA, US
Marc Unger - San Mateo CA, US

Fuidigm Corporation - South San Francisco CA

C03C 25/68
G01N 1/10

216 84, 216 86, 436180, 324 711

The presence of a detectable entity within a detection volume of a microfabricated elastomeric structure is sensed through a change in the electrical or magnetic environment of the detection volume. In embodiments utilizing electronic detection, an electric field is applied to the detection volume and a change in impedance, current, or combined impedance and current due to the presence of the detectable entity is measured. In embodiments utilizing magnetic detection, the magnetic properties of a magnetized detected entity alter the magnetic field of the detection volume. This changed magnetic field induces a current which can reveal the detectable entity. The change in resistance of a magnetoresistive element may also reveal the passage of a magnetized detectable entity.

7666361, Feb 23, 2010

Apr 5, 2004

10/818642

Lincoln McBride - Belmont CA, US
Marc Unger - San Mateo CA, US
Michael Lucero - South San Francisco CA, US
Hany Ramez Nassef - San Mateo CA, US
Geoff Facer - San Francisco CA, US
Yong Yi - Burlingame CA, US

Fluidigm Corporation - South San Francisco CA

B01L 3/00

422102, 422100

A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

20220323957, Oct 13, 2022

Jan 19, 2022

17/579559

- Menlo Park CA, US
Geoff FACER - Redwood City CA, US
Susana JETT - Newark CA, US
Kevin TRAVERS - Menlo Park CA, US

B01L 3/00
G01N 15/06

The present invention relates methods for separation and/or concentration of cell nuclei and/or live cells from cellular and nuclear debris, and dead cells using magnetic levitation.

20230112068, Apr 13, 2023

Oct 7, 2022

17/938825

- Menlo Park CA, US
Geoff Facer - Menlo Park CA, US
Gang Sun - Cupertino CA, US
Lesley Suzanne Weaver - Palo Alto CA, US

LevitasBio, Inc. - Menlo Park CA

B01L 3/00
G01N 15/06

Magnetic levitation particle separation systems and methods for use with multi-channel flow cells. The system may include a core for receiving and holding the flow cell, with upper and lower clamps for securing the flow cell and positioning it relative to an array of magnets. The system is configured to image particle separation in processing channels of the flow cell, and to regulate the flow cell's temperature. The core may be removable as a single unit, facilitating reconfiguration of the system.

20210339252, Nov 4, 2021

Jul 5, 2021

17/367619

- Sydney, AU
Amy Twite - Berkeley CA, US
Geoff Facer - Redwood City CA, US
Katherine Lau - Alameda CA, US
Adrian Lievano - San Francisco CA, US
Julyana Acevedo - Berkeley CA, US

B01L 3/00
A61K 35/15
A61K 35/17
C12N 15/90
C12N 13/00
C12N 15/64
C12N 15/87

A method and device for transfecting a cell to introduce an exogenous material into the cell. The method includes exposing the cell to a region of unsteady flow in the presence of an electric field to encourage introduction of the exogenous material into a cell without lysing the cell.

20200385759, Dec 10, 2020

Nov 2, 2018

16/474996

- Sydney, AU
Amy Twite - Berkeley CA, US
Geoff Facer - Redwood City CA, US
Katherine Lau - Alameda CA, US
Adrian Lievano - San Francisco CA, US
Julyana Acevedo - Berkeley CA, US

C12N 15/87
C12N 15/64
C12N 13/00

A method and device for transfecting a cell to introduce an exogenous material into the cell. The method includes exposing the cell to a region of unsteady flow in the presence of an electric field to encourage introduction of the exogenous material into a cell without lysing the cell.

20190321825, Oct 24, 2019

Jun 29, 2019

16/458019

- Sydney, AU
Amy Twite - Berkeley CA, US
Geoff Facer - Redwood City CA, US
Katherine Lau - Alameda CA, US
Adrian Lievano - San Francisco CA, US
Julyana Acevedo - Berkeley CA, US

B01L 3/00
C12N 15/90
A61K 35/17
A61K 35/15

A method and device for transfecting a cell to introduce an exogenous material into the cell. The method includes exposing the cell to a region of unsteady flow in the presence of an electric field to encourage introduction of the exogenous material into a cell without lysing the cell.

20160289669, Oct 6, 2016

Jan 22, 2016

15/004618

- Franklin Lakes NJ, US
Stephen P.A. Fodor - Palo Alto CA, US
Glenn Fu - Dublin CA, US
Geoff Facer - Redwood City CA, US
David Stern - Mountain View CA, US
Janice Lai - Mountain View CA, US
Ari Chaney - Palm Beach Gardens FL, US
Phillip Spuhler - Redwood City CA, US
Sixing Li - Redwood City CA, US
Xiaohua Chen Huang - Mountain View CA, US
Kimberly R. Metzler - San Francisco CA, US
Elisabeth Marie Walczak - Menlo Park CA, US

C12N 15/10
C12Q 1/68
B01L 3/00

Disclosed herein are devices and systems comprising a) a substrate comprising at least 100 microwells and a plurality of beads, wherein a plurality of the at least 100 microwells each contain a single bead, and wherein the ratio of the average diameter of the microwells to the diameter of the beads ranges from about 1.2 to about 1.8; b) a flow cell in fluid communication with the substrate; and c) at least one inlet port and at least one outlet port, wherein the at least one inlet port and at least one outlet port are capable of directing a flow of a fluid through the flow cell, thereby contacting the microwells with the fluid.