Inventors:
Thomas E. DAmbra - Wynantskill NY
Garry M. Pilling - East Nassau NY
Assignee:
Albany Molecular Research, Inc. - Albany NY
International Classification:
C07D21134
US Classification:
546210, 546209, 546216, 546239, 546240, 544 34, 544 96, 544299, 540467, 540470, 540488, 540492
Abstract:
The present invention relates to a method for preparing piperidine derivative compounds by converting, with a piperidine compound, regioisomers having the formula: where Z is or and where m is 1 or 4-6; Q and Y are the same or different and are selected from the group consisting of O, S, and NR ; R and R are the same or different and are selected from the group consisting of hydrogen, an alkyl moiety, an aryl moiety, OR , SR , and NR R ; X is halogen, OR , SR , NR R , OSO R , or NHSO R ; R , R , R , R , and R are the same or different and are selected from the group consisting of hydrogen, an alkyl moiety, and an aryl moiety; and A is a substituent of its ring and is selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, alkoxy, and other substituents.