Dinah S. Singer - Chevy Chase MD Leonard Kohn - Bethesda MD Edna Mozes - Rehovot, IL Motoyasu Saji - Rockville MD Jocelyn Weissman - Silver Spring MD Giorgio Napolitano - Rockville MD Fred D. Ledley - Houston TX
International Classification:
C12Q 102 C12Q 100 G01N 3353 A01N 6100
US Classification:
435 29
Abstract:
The present invention provides methods for treating autoimmune diseases in mammals and for preventing or treating transplantation rejection in a transplant recipient. The methods of treatment involve the use of drugs capable of suppressing expression of MHC Class I molecules. In particular the use of the drug methimazole to suppress expression of MHC Class I molecules in the treatment of autoimmune diseases and the prevention or treatment of rejection in a transplant recipient is disclosed. In addition in vivo and in vitro assays are provided for the assessment and development of drugs capable of suppressing MHC Class I molecules.
Methods For Assessing The Ability Of A Candidate Drug To Suppress Mhc Class I Expression
Dinah S. Singer - Chevy Chase MD Leonard Kohn - Bethesda MD Edna Mozes - Rehovot IL Motoyasu Saji - Rockville MD Jocelyn Weissman - Silver Spring MD Giorgio Napolitano - Rockville MD Fred D. Ledley - Houston TX
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C12Q 168 C12P 1934 C07H 2104
US Classification:
435 6
Abstract:
The present invention provides methods for treating autoimmune diseases in mammals and for preventing or treating transplantation rejection in a transplant recipient. The methods of treatment involve the use of drugs capable of suppressing expression of MHC Class I molecules. In particular the use of the drug methimazole to suppress expression of MHC Class I molecules in the treatment of autoimmune diseases and the prevention or treatment of rejection in a transplant recipient is disclosed. In addition in vivo and in vitro assays are provided for the assessment and development of drugs capable of suppressing MHC Class I molecules.