Frances E Nargi

7422860, Sep 9, 2008

Dec 1, 2004

11/001583

Eric D. Schwoebel - Woburn MA, US
James D. Harper - Boston MA, US
Martha S. Petrovick - Barre MA, US
Frances E. Nargi - Littleton MA, US
Todd H. Rider - Littleton MA, US
Kristine E. Hogan - Danvers MA, US
Richard H. Mathews - Chelmsford MA, US
Joseph Lacirignola - Beverly MA, US
Mark Hennessy - Cambridge MA, US
Trina R. Vian - Groton MA, US
Rose M. Joseph - Westford MA, US
Raymond S. Uttaro - Lexington MA, US
Shaun Berry - Chelmsford MA, US
Bernadette Johnson - Hollis NH, US
Mark A. Hollis - Concord MA, US

Massachusetts Institute of Technology - Cambridge MA

G01N 33/53

435 71

The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.

7947509, May 24, 2011

May 7, 2007

11/800607

James Douglas Harper - Boston MA, US
Richard Hart Mathews - Chelmsford MA, US
Bernadette Johnson - Hollis NH, US
Martha Susan Petrovick - Barre MA, US
Ann Rundell - West Lafayette IN, US
Frances Ellen Nargi - Concord MA, US
Timothy Stephens - Lexington MA, US
Linda Marie Mendenhall - Acton MA, US
Mark Alexander Hollis - Concord MA, US
Albert M. Young - Fishkill NY, US
Todd H. Rider - Littleton MA, US
Eric David Schwoebel - Belmont MA, US
Trina Rae Vian - Groton MA, US

Massachusetts Institute of Technology - Cambridge MA

G01N 21/00
G01N 21/01
G01N 21/62
G01N 21/63
G01N 21/64
G01N 33/52

436164, 422 55, 422 58, 422 681, 422 8205, 422 8206, 422 8207, 422 8208, 435 71, 435 72, 435 721, 4352871, 4352872, 4352873, 4352883, 4352887, 435172

The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

8067184, Nov 29, 2011

Jul 3, 2008

12/217471

Eric D. Schwoebel - Woburn MA, US
James D. Harper - Boston MA, US
Martha S. Petrovick - Barre MA, US
Frances E. Nargi - Littleton MA, US
Todd H. Rider - Littleton MA, US
Kristine E. Hogan - Danvers MA, US
Richard H. Mathews - Chelmsford MA, US
Joseph Lacirignola - Beverly MA, US
Mark Hennessy - Cambridge MA, US
Trina R. Vian - Groton MA, US
Rose M. Joseph - Westford MA, US
Raymond S. Uttaro - Lexington MA, US
Shaun Berry - Chelmsford MA, US
Bernadette Johnson - Hollis NH, US
Mark A. Hollis - Concord MA, US

Massachusetts Institute of Technology - Cambridge MA

G01N 33/53
C12Q 1/00

435 71, 435 4, 435 29

The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.

8216797, Jul 10, 2012

Nov 30, 2006

12/085495

Eric Schwoebel - Woburn MA, US
James Harper - Jamaica Plain MA, US
Martha S. Petrovick - Barre MA, US
Frances Nargi - Littleton MA, US
Mark Hollis - Concord MA, US
Bernadette Johnson - Hollis NH, US
Joseph Lacirignola - Beverly MA, US
Richard Mathews - Chelmsford MA, US
Kristine Hogan - Danvers MA, US
Trina Vian - Groton MA, US
Allan Heff - Newton MA, US
Mark Hennessy - Falls Church VA, US
Songeeta Palchaudhuri - Somerville MA, US
Todd Rider - Littleton MA, US

Massachusetts Institute of Technology - Cambridge MA

G01N 33/53

435 72, 435 71, 435 794, 435403, 436519, 436536

The invention described herein provides methods for the detection of target particles, such as pathogens, soluble antigens, nucleic acids, toxins, chemicals, plant pathogens, blood borne pathogens, bacteria, viruses and the like. Also described is an emittor cell comprising a receptor, wherein the receptor can be an antibody or an Fc receptor, and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more receptors on the emittor cell. Also provided are optoelectronic sensor devices for detecting a target particle in a sample, including in a plurality of samples.

20040121402, Jun 24, 2004

Jan 16, 2004

10/467242

James Harper - Boston MA, US
Richard Mathews - Chelmsford MA, US
Bernadette Johnson - Hollis NH, US
Martha Petrovik - Boston MA, US
Ann Rundell - West Lafayette IN, US
Frances Nargi - Concord MA, US
Timothy Stephens - Lexington MA, US
Linda Mendenhall - Acton MA, US
Mark Hollis - Concord MA, US
Albert Young - Fiskhill NY, US
Todd Rider - Littleton MA, US
Eric Schwoebel - Belmont ,MA, US
Trina Vian - Groton MA, US

G01N033/53
C12M001/34

435/007100, 435/287200

The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

20090221056, Sep 3, 2009

Nov 30, 2006

12/085486

Martha S. Petrovick - Barre MA, US
Eric D. Schwoebel - Woburn MA, US
Frances E. Nargi - Littleton MA, US
James D. Harper - Jamaica Plain MA, US
Todd H. Rider - Littleton MA, US

C12N 1/12

4352576

Methods to produce cells that remain viable at ambient or non-refrigerated temperatures, or which can be stored in a dry state are described. In particular, cell preservation is for long term storage of cells, such as mammalian cells, at ambient or non-refrigerated temperatures, while retaining cell viability. Also provided are sensor cells that can detect target particles, biological agents or other materials and which remain viable at ambient or non-refrigerated temperatures, or which can be stored in a dry state.

20120135404, May 31, 2012

Oct 6, 2011

13/267276

James D. Harper - Boston MA, US
Martha S. Petrovick - Barre MA, US
Frances E. Nargi - Littleton MA, US
Todd H. Rider - Littleton MA, US
Kristine E. Hogan - Danvers MA, US
Richard H. Mathews - Chelmsford MA, US
Joseph Lacirignola - Beverly MA, US
Mark Hennessy - Cambridge MA, US
Trina R. Vian - Groton MA, US
Rose M. Joseph - Westford MA, US
Raymond S. Uttaro - Lexington MA, US
Shaun Berry - Chelmsford MA, US
Bernadette Johnson - Hollis MA, US
Mark A. Hollis - Concord MA, US

Massachusetts Institute of Technology - Cambridge MA

G01N 21/75
C12M 1/34

435 611, 4352872

The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.

20120190006, Jul 26, 2012

Mar 3, 2011

13/039780

James Douglas Harper - Boston MA, US
Richard Hart Mathews - Chelmsford MA, US
Bernadette Johnson - Hollis NH, US
Martha Susan Petrovick - Barre MA, US
Ann Rundell - West Lafayette IN, US
Frances Ellen Nargi - Concord MA, US
Timothy Stephens - Lexington MA, US
Linda Marie Mendenhall - Acton MA, US
Mark Alexander Hollis - Concord MA, US
Albert M. Young - Fishkill NY, US
Todd H. Rider - Littleton MA, US
Eric David Schwoebel - Belmont MA, US
Trina Rae Vian - Groton MA, US

G01N 21/84

435 5, 435 724

The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.