Inventors:
Daniel Benigni - Skaneateles NY, US
Robert Stankavage - Bridgeport NY, US
Shu-Jen Chiang - Manlius NY, US
Hsing Hou - Manlius NY, US
Bruce Eagan - Fayetteville NY, US
Dennis Gu - Skokie IL, US
David Hou - Baldwinsville NY, US
Les Mintzmyer - Manlius NY, US
Thomas Tully - Middlesex NJ, US
Brian Davis - Milltown NJ, US
Ivan Hargro - Roselle NJ, US
Mark Mascari - East Syracuse NY, US
Gabriel Galvin - Manlius NY, US
Gregory Stein - Mallory NY, US
Cary McConlogue - Plainsboro NJ, US
Fahri Comezoglu - Kendall Park NJ, US
International Classification:
C12P017/14
C07D417/02
Abstract:
The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.