US Patent:
20120244604, Sep 27, 2012
Inventors:
Pavel Kornilovich - Corvallis OR, US
Erik D. Torniainen - Redmond WA, US
Alexander Govyadinov - Corvallis OR, US
David P. Markel - Albany OR, US
International Classification:
C12M 1/36
C12M 1/38
Abstract:
In one embodiment, a polymerase chain reaction (PCR) system includes a mixture chamber, a denature chamber, an annealing chamber, an extension chamber, and a product chamber, that are fluidically coupled to one another through a plurality of microfluidic channels. An inertial pump is associated with each microfluidic channel, and each inertial pump includes a fluid actuator integrated asymmetrically within its associated microfluidic channel. The fluid actuators are capable of selective activation to circulate fluid between the chambers in a controlled cycle.