Inventors:
Hermona Soreq - Jerusalem, IL
Eran Meshorer - Rockville MD, US
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem - Jerusalem
International Classification:
C12N 9/18
C07H 21/04
C12N 5/07
Abstract:
A novel form of acetylcholinesterase (AChE) is provided, N-AChE, which bears a transmembrane domain. Exons encoding this novel form, the peptide comprising, the transmembrane domain, as well as antibodies recognizing the same are also provided. N-AChE expression in the hippocampus is correlated with Alzheimer's disease. Secreted forms of AChE are also provided, and methods of producing AChE protein are, also described.