Inventors:
Jeffrey D. Chulay - Chapel Hill NC, US
Sergey Dryga - Chapel Hill NC, US
Elizabeth A. Reap - Durham NC, US
Robert A. Olmsted - Chapel Hill NC, US
John S. Morris - Cary NC, US
Assignee:
Alpha Vax, Inc. - Research Triangle Park NC
International Classification:
A61K 39/295
A61K 39/245
C12N 7/01
C12N 15/86
US Classification:
4241991, 4241921, 4242301, 4352351, 4353201
Abstract:
The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising alphavirus replicon RNAs, wherein a first replicon RNA comprises nucleic acid encoding cytomegalovirus pp65 and IE1 protein or immunogenic fragments thereof, and a second replicon RNA comprises nucleic acid encoding cytomegalovirus gB protein or an immunogenic fragment thereof, and wherein each of the two replicon RNAs is contained within a separate alphavirus replicon particle.