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Ehud R Goldin

from Sunnyvale, CA
Age ~69
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Also known as:
Ehud N
Related to:
Aleksandra Burtseva, 40Kirby Weinberg, 36Laura P Weinberg, 71Ali Weinberg, 41Michael Smith, 61
Connected to:
Ariel S Goldin, 31Brian D Goldin, 52Dana L Goldin, 51Diane C Goldin, 74Diane Goldin, 67Emma R Goldin, 37Florence S Goldin, 94Gary J Goldina, 53Hana Goldin, 39Katia Goldin, 65

Ehud Goldin Phones & Addresses

  • Sunnyvale, CA
  • Cupertino, CA
  • Mountain View, CA
  • 606 Rollins Ave, Rockville, MD 20852 (301) 468-2624
  • 1712 Wilmart St, Rockville, MD 20852
  • 606 Rollins Ave, Rockville, MD 20852

Work

Company: Nih Position: Staff scientist

Education

School / High School: Weizmann Institute of Science

Skills

Biochemistry • Cell Biology • Life Sciences • Neuroscience • Drug Discovery • Animal Models • Tissue Culture • Protein Chemistry • Developing Models For Human Disease • Neuropathology • Professional Mentoring • Research Design • Publication Writing • Medical Genetics • Healthcare Consulting • Stem Cell Research • Statistical Modeling • Teamwork • Cost Planning • Electron Microscopy • Qrt Pcr • Mass Spectrometry • Fluorescence Spectroscopy • Clinical Pharmacology • Brain Research • Animal Surgery • Clinical Research • Protein Assays • Protein Electrophoresis • Transient Transfection • Research Consulting • Team Management • Patents • Antibodies • Genome Sequencing • Blotting • Genome Analysis • Microarray • Calcium Imaging • Gene Silencing • Subcellular Fractionation

Languages

Hebrew • English

Interests

Science and Technology • Health

Industries

Research

Resumes

Resumes

Ehud Goldin Photo 1

Vice President Biology

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Location:
10 Center St, Washington Grove, MD 20880
Industry:
Research
Work:
NIH
Staff Scientist
Education:
Weizmann Institute of Science
Skills:
Biochemistry
Cell Biology
Life Sciences
Neuroscience
Drug Discovery
Animal Models
Tissue Culture
Protein Chemistry
Developing Models For Human Disease
Neuropathology
Professional Mentoring
Research Design
Publication Writing
Medical Genetics
Healthcare Consulting
Stem Cell Research
Statistical Modeling
Teamwork
Cost Planning
Electron Microscopy
Qrt Pcr
Mass Spectrometry
Fluorescence Spectroscopy
Clinical Pharmacology
Brain Research
Animal Surgery
Clinical Research
Protein Assays
Protein Electrophoresis
Transient Transfection
Research Consulting
Team Management
Patents
Antibodies
Genome Sequencing
Blotting
Genome Analysis
Microarray
Calcium Imaging
Gene Silencing
Subcellular Fractionation
Interests:
Science and Technology
Health
Languages:
Hebrew
English

Publications

Us Patents

Differential Expression Of Molecules Associated With Acute Stroke

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US Patent:
7749700, Jul 6, 2010
Filed:
Jun 17, 2005
Appl. No.:
11/155835
Inventors:
Alison E. Baird - Brooklyn NY, US
David F. Moore - Rockville MD, US
Ehud Goldin - Rockville MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C12Q 1/68
C12M 1/34
US Classification:
435 6, 4352871
Abstract:
Methods are provided for evaluating a stroke, for example for determining whether a subject has had an ischemic stroke, determining the severity or likely neurological recovery of a subject who has had an ischemic stroke, and determining a treatment regimen for a subject who has had an ischemic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression in ischemic stroke related genes (or proteins), such as white blood cell activation and differentiation genes (or proteins), genes (or proteins) related to hypoxia, genes (or proteins) involved in vascular repair, and genes (or proteins) related to a specific peripheral blood mononuclear cell (PBMC) response to the altered cerebral microenvironment. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of an ischemic stroke-related molecule.

Gene Encoding A New Trp Channel Is Mutated In Mucolipidosis Iv

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US Patent:
20030064363, Apr 3, 2003
Filed:
May 8, 2001
Appl. No.:
09/851494
Inventors:
Ehud Goldin - Rockville MD, US
Susan Slaugenhaupt - Quincy MA, US
Mei Sun - Rockville MD, US
James Acierno - Quincy MA, US
Assignee:
The ML4 Foundation and President and Fellows of Havard College
International Classification:
C12Q001/68
C07H021/04
C12N009/20
C12P021/02
C12N005/06
US Classification:
435/006000, 435/069100, 435/198000, 435/320100, 435/325000, 536/023200
Abstract:
The present invention relates to identification of a gene that is inactivated in a mucolipidosis condition. In particular, the invention concerns mutations that disrupt a mucolipin, preferably MCOLN1, in mucolipidosis IV. Recombinant nucleic acids encoding mutant forms of MCOLN1, oligonucleotides specific for such mutations, and diagnostic and therapeutic applications related to these discoveries, are also contemplated.

Differential Expression Of Molecules Associated With Intra-Cerebral Hemorrhage

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US Patent:
20100086481, Apr 8, 2010
Filed:
Jul 11, 2007
Appl. No.:
12/307910
Inventors:
Alison E. Baird - Brooklyn NY, US
David F. Moore - Rockville MD, US
Ehud Goldin - Rockville MD, US
Kory Johnson - Rockville MD, US
International Classification:
C12Q 1/68
C40B 40/06
C40B 40/10
A61K 49/00
US Classification:
424 91, 435 6, 506 16, 506 18
Abstract:
Methods are provided for evaluating a stroke, for example for determining whether a subject has had a hemorrhagic stroke, determining the severity or likely neurological recovery of a subject who has had a hemorrhagic stroke, and determining a treatment regimen for a subject who has had a hemorrhagic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression of hemorrhagic stroke related genes (or proteins), such as genes (or proteins) involved in suppression of the immune response, genes (or proteins) involved in vascular repair, genes (or proteins) involved in the acute inflammatory response, genes (or proteins) involved in cell adhesion, genes (or proteins) involved in hypoxia, genes (or proteins) involved in signal transduction, and genes (or proteins) involved in the response to the altered cerebral microenvironment. Arrays and kits are provided that can be used in the disclosed methods. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of a hemorrhagic stroke-related molecule.

Differential Expression Of Molecules Associated With Acute Stroke

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US Patent:
20100267582, Oct 21, 2010
Filed:
Jul 1, 2010
Appl. No.:
12/829229
Inventors:
ALISON E. BAIRD - BETHESDA MD, US
DAVID F. MOORE - ROCKVILLE MD, US
EHUD GOLDIN - ROCKVILLE MD, US
International Classification:
C40B 30/04
C12Q 1/68
C40B 40/08
US Classification:
506 9, 435 6, 506 17
Abstract:
Methods are provided for evaluating a stroke, for example for determining whether a subject has had an ischemic stroke, determining the severity or likely neurological recovery of a subject who has had an ischemic stroke, and determining a treatment regimen for a subject who has had an ischemic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression in ischemic stroke related genes (or proteins), such as white blood cell activation and differentiation genes (or proteins), genes (or proteins) related to hypoxia, genes (or proteins) involved in vascular repair, and genes (or proteins) related to a specific peripheral blood mononuclear cell (PBMC) response to the altered cerebral microenvironment. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of an ischemic stroke-related molecule.

Substituted Pyrazolopyrimidines As Glucocerebrosidase Activators

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US Patent:
20180263988, Sep 20, 2018
Filed:
May 18, 2018
Appl. No.:
15/983844
Inventors:
- Bethesda MD, US
Noel Southall - Potomac MD, US
Ehud Goldin - Rockville MD, US
Wei Zheng - Potomac MD, US
Samarjit Patnaik - Gaithersburg MD, US
Ellen Sidransky - Bethesda MD, US
Omid Motabar - Darnestown MD, US
Wendy Westbroek - Rockville MD, US
International Classification:
A61K 31/519
C07D 487/04
A61K 31/5377
Abstract:
Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I)in which variables R-Rand X are described in the application.

Substituted Pyrazolopyrimidines As Glucocerebrosidase Activators

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US Patent:
20160346284, Dec 1, 2016
Filed:
Apr 28, 2016
Appl. No.:
15/141275
Inventors:
- Bethesda MD, US
Noel Southall - Potomac MD, US
Ehud Goldin - Rockville MD, US
Wei Zheng - Potomac MD, US
Samarjit Patnaik - Gaithersburg MD, US
Ellen Sidransky - Bethesda MD, US
Omid Motabar - Darnestown MD, US
Wendy Westbroek - Rockville MD, US
International Classification:
A61K 31/519
A61K 31/5377
Abstract:
Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I)in which variables R-Rand X are described in the application.

Salicylic Acid Derivatives Useful As Glucocerebrosidase Activators

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US Patent:
20150065469, Mar 5, 2015
Filed:
Mar 15, 2013
Appl. No.:
14/388494
Inventors:
- Bethesda MD, US
- Lawrence KS, US
Samarjit Patnaik - Gaithersburg MD, US
Noel Southall - Potomac MD, US
Ellen Sidransky - Bethesda MD, US
Ehud Goldin - Rockville MD, US
Wendy Westbroek - Rockville MD, US
Elma Aflaki - Rockville MD, US
Steven Andrew Rogers - Lawrence KS, US
Frank John Schoenen - Lawrence KS, US
International Classification:
C07C 235/64
US Classification:
514166, 564168
Abstract:
Compounds of Formula (I) and the pharmaceutically acceptable salts thereof are disclosed. The variables. R-R, m, n, o, and p are disclosed herein. The compounds are useful for treating Gaucher disease and inhibiting the onset of Gaucher disease symptoms in a patient having a GBA gene mutation and for treating Parkinson's disease. Pharmaceutical compositions containing compounds of Formula (I) and methods of treatment comprising administering compounds of Formula (I) are also disclosed.

Substituted Pyrazolopyrimidines As Glucocerebrosidase Activators

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US Patent:
20140249145, Sep 4, 2014
Filed:
Dec 8, 2011
Appl. No.:
13/991816
Inventors:
Juan Jose Marugan - Gaithersburg MD, US
Noel Southall - Potomac MD, US
Ehud Goldin - Rockville MD, US
Wei Zheng - Potomac MD, US
Samarjit Patnaik - Gaithersburg MD, US
Ellen Sidransky - Bethesda MD, US
Omid Motabar - Darnestown MD, US
Wendy Westbroek - Rockville MD, US
Assignee:
THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Serv - Bethesda MD
International Classification:
C07D 487/04
US Classification:
5142332, 544281, 5142593, 51425216, 544250, 514267, 544117
Abstract:
Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I)in which variables R-Rand X are described in the application.
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Ehud R Goldin from Sunnyvale, CA, age ~69 Get Report