US Patent:
20130210896, Aug 15, 2013
Inventors:
CITY OF HOPE - Duarte CA, US
Leying ZHANG - Covina CA, US
Darya ALIZADEH - Mission Viejo CA, US
Dongchang ZHAO - Duarte CA, US
Jacob BERLIN - Duarte CA, US
International Classification:
A61K 47/48
Abstract:
One aspect of the invention relates to a nanoparticle conjugated CpG (NANO-CpG) composition and pharmaceutical composition thereof, and the preparation methods thereof. Another aspect of the invention relates to a method for using the NANO-CpG to improve CpG delivery into brain tumor associated inflammatory cells in a subject. Another aspect of the invention relates to a method for treating or preventing a method for treating and/or preventing a brain tumor in a subject comprising administering a therapeutically effective amount of the NANO-CpG or a pharmaceutical composition thereof to the subject. In one embodiment, a subject treated with the NANO-CpG composition disclosed herein or a pharmaceutical composition thereof developed immunity to brain tumor.