US Patent:
20140235637, Aug 21, 2014
Inventors:
- Brisbane CA, US
Scott D. Seiwert - Seattle WA, US
Vladimir Serebryany - Burlingame CA, US
Donald Ruhrmund - San Francisco CA, US
Leonid D. Beigelman - San Mateo CA, US
Luca Francesco Mario Raveglia - Milano, IT
Stefania Vallese - Cardano al Campo (VA), IT
Ivana Bianchi - Fagnano Olona (VA), IT
Tao Hu - Shanghai, CN
Assignee:
InterMune, Inc. - Brisbane CA
International Classification:
C07D 213/64
C07D 417/04
C07D 409/04
C07D 405/04
C07D 213/85
US Classification:
5142355, 546290, 514345, 546300, 514351, 546301, 544322, 514256, 546257, 514334, 5462824, 514338, 5462837, 546288, 514344, 5462804, 514336, 5462704, 514342, 544131
Abstract:
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.