US Patent:
20040167189, Aug 26, 2004
Inventors:
Dmitry Bulavin - Washington DC, US
Galina Belova - Rockville MD, US
Albert Fornace - Bethesda MD, US
Assignee:
The Government of the U.S.A., as Represented by the Secretary, Dept. of Health and Human Services - Rockville MD
International Classification:
A61K031/4245
A61K031/185
Abstract:
The invention provides a method of treating cancer in a mammal that expresses the same level or a higher level of Wip1 as compared to a mammal of the same species that does not have cancer, and a method of inhibiting Wip1 in a cell. The invention also provides pharmaceutical compositions comprising a compound selected from the group consisting of Compounds A-N, and a method of making a cancer therapeutic composition. Also provided is a compound selected from the group consisting of Compounds A-N, a method of screening a compound for Wip1-inhibiting activity, and a method of determining the efficacy with which a test compound inhibits Wip1.