Inventors:
Dimitris Anastassiou - Tenafly NJ, US
Vinay Varadan - Hastings-on-Hudson NY, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
G01N 33/48
C12Q 1/68
G06F 7/60
G06G 7/58
US Classification:
702 19, 435 6, 702 20, 703 2, 703 11
Abstract:
A method is provided for selecting two or more genes from gene expression data. In the method, gene expression data for a plurality of genes is provided, where the gene expression data include expression levels for each of the plurality of genes. The gene expression data is discretized. Based on the discretized gene expression data, the synergy among the plurality of genes with respect to a phenotype, for example, presence or absence of a disease in a tissue, is evaluated. Two or more genes whose synergy exceeds a predetermined threshold are selected. A system implementing the method is also provided.