US Patent:
20120184491, Jul 19, 2012
Inventors:
Frederick Sachs - Buffalo NY, US
Philip Gottlieb - Buffalo NY, US
Thomas Suchyna - Amherst NY, US
Seth L. Alper - Boston MA, US
David H. Vandorpe - Watertown MA, US
Chang Xu - Mount Kisco NY, US
International Classification:
A61K 38/16
C12N 5/02
A61P 7/06
Abstract:
The present invention provides methods and compositions for inhibiting calcium permeable cation conductance of red blood cells from individuals afflicted with sickle cell anemia. The method comprises exposing the cells to the peptide GsMTx4 and/or variants thereof.