Inventors:
David Bialosky - Pittsburgh PA, US
Jodi Martin - Imperial PA, US
International Classification:
A61K031/425
A61K031/13
A61K047/00
US Classification:
424/405000, 514/365000, 514/672000, 514/777000, 514/781000, 516/905000
Abstract:
Aqueous dispersions of 2-(4-thiazolyl)-benzimidazole (TBZ), alone or in combination with 1,2-dibromo-2,4-dicyanobutane (DBDCB), and processes for making the same, are disclosed. These processes generally comprise mixing a xanthan gum with water, adding TBZ and mixing until uniform. DBDCB dispersions are prepared by mixing xanthan gum with water, adding DBDCB, maintaining the mixture at a temperature below about 40 C., grinding the mixture and mixing until uniform. The TBZ and DBDCB dispersions are then blended to prepare a dispersion containing both active ingredients. A method for inhibiting microbial growth utilizing these dispersions is also claimed.