Inventors:
Danica Ramljak - McLean VA, US
Robert B. Dickson - Kensington MD, US
Assignee:
Mars, Incorporated - McLean VA
International Classification:
A61K 31/35
Abstract:
This invention relates to methods of inducing dephosphorylation of a hyperphosphorylated cell cycle regulatory protein in a tumor cell in which hyperphosphorylation of said protein contributed to cell transformation, the method comprising contacting the tumor cell with a procyanidin oligomer of five monomeric units connected via a C-4→C-8 linkage. Examples of such compounds are [EC-(4β→8)]-EC, and [EC-(4β→8)]-EC-(4β→8)-C, wherein EC is epicatcchin and C is catechin.