Inventors:
Kate Ashton - Westlake Village CA, US
Michael David Bartberger - Sherman Oaks CA, US
Yunxin Bo - Thousand Oaks CA, US
Marian C. Bryan - West Hills CA, US
Michael Croghan - Thousand Oaks CA, US
Christopher Harold Fotsch - Thousand Oaks CA, US
Clarence Henderson Hale - Camarillo CA, US
Roxanne Kay Kunz - Santa Monica CA, US
Longbin Liu - Thousand Oaks CA, US
Nobuko Nishimura - West Hills CA, US
Mark H. Norman - Thousand Oaks CA, US
Lewis Dale Pennington - Ventura CA, US
Steve Fong Poon - Woodland Hills CA, US
Markian Myroslaw Stec - Thousand Oaks CA, US
David Joseph St. Jean, JR. - Camarillo CA, US
Nuria A. Tamayo - Newbury Park CA, US
Christopher Michael Tegley - Thousand Oaks CA, US
Kevin Chao Yang - San Gabriel CA, US
Assignee:
AMGEN INC. - Thousand Oaks CA
International Classification:
A61K 31/496
A61P 27/02
A61P 13/12
A61P 25/00
A61P 27/12
A61P 27/06
A61P 3/04
A61P 15/00
C07D 409/12
C07D 295/26
A61K 31/495
C07D 403/12
C07D 401/12
C07D 409/14
A61K 31/506
C07D 213/46
A61K 31/4418
C07C 317/22
A61K 31/10
C07D 405/12
C07D 417/10
C07D 413/14
A61K 31/5377
C07D 498/08
A61K 31/5386
C07D 491/107
C07D 417/14
A61K 31/541
C07D 401/14
C07D 491/048
C07D 471/08
C07D 211/54
A61K 31/451
A61K 31/501
C07D 487/04
A61K 31/4985
C07D 403/04
C07D 491/08
A61P 3/10
US Classification:
5142102, 544379, 51425213, 544383, 51425503, 544371, 51425405, 544360, 51425312, 544295, 51425214, 546344, 514277, 568 32, 514709, 5142541, 544369, 51425402, 51425403, 544121, 5142358, 544105, 5142305, 544372, 51425401, 544370, 544230, 544 582, 5142278, 51425408, 546216, 514327, 544238, 51425202, 544350, 514249, 544357, 51425211, 544367, 514710, 544362, 51425304
Abstract:
The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts thereof,that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.
