Inventors:
Jay P. Morgenstern - Boston MA, US
Christine B. Bizinkauskas - Marlborough MA, US
Andrzej Konieczny - Arlington MA, US
Andrew W. Brauer - Salem MA, US
Assignee:
Heska Corporation - Fort Collins CO
International Classification:
G01N 33/53
C07H 21/04
A61K 39/00
A61K 38/00
A01N 38/18
US Classification:
435 71, 536 231, 536 235, 4241841, 4241851, 4242751, 514 2, 514 12, 530300, 530350
Abstract:
Isolated nucleic acids encoding allergens of Can f I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can f I or Can f II nucleic acid in a sample or for the recombinant production of peptides having a Can f I or Can f II activity. Peptides having a Can f I or Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.