Inventors:
Edward F. Leonard - Bronxville NY, US
Alan C. West - Tenafly NJ, US
Christian Paul Aucoin - New York NY, US
Edgar E. Nanne - Bronx NY, US
Assignee:
The Trustees of Columbia in the City of New York - New York NY
International Classification:
B01D 61/38
B01D 61/24
B01D 61/14
B01D 11/00
A61M 1/34
A61M 37/00
US Classification:
210203, 210 97, 210137, 210200, 210209, 210511, 210644, 210645, 210646, 210647, 210649, 210650, 210651, 210634, 210643, 210767, 210806, 604 401, 604 501, 604 601, 604 602, 604 609, 422 81, 422 82, 422 99, 209155, 209196
Abstract:
A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.