Inventors:
Chris Allen Broka - Foster City CA
Jeffrey Allen Campbell - Fremont CA
Jian Jeffrey Chen - Santa Clara CA
Sharon Marie Dankwardt - Foster City CA
Nancy Delaet - San Diego CA
Leslie Ann Robinson - Los Altos CA
Keith Adrian Murray Walker - Los Altos CA
Assignee:
Syntex (U.S.A.) LLC - Palo Alto CA
International Classification:
A61K 31445
US Classification:
514321, 5142275, 5142278, 5142282, 5142312, 5142338, 5142345, 5142352, 5142355, 514255, 514311, 514314, 514318, 514322, 514323, 514326, 514337, 514338, 514339, 514394, 514412, 514419, 514422, 514438, 514443, 514464, 544 584, 544124, 544128, 544139, 544143, 544153, 544159, 544363, 544370, 544373, 544377, 544386, 546193, 546197, 546199, 546201, 546229, 546264, 5462734, 5462774, 548495, 548517, 548518, 548561, 549 59, 549 75, 549 76, 549 77, 549440, 549448, 549452
Abstract:
A compound of the Formula (I): wherein Z, R , R, and Ar are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use, and methods for preparing the compounds.