Inventors:
John L. Krstenansky - Palo Alto CA
John J. Nestor - Cupertino CA
Teresa H. Ho - Los Altos CA
Brian H. Vickery - Mountain View CA
Chinh T. Bach - San Jose CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C12N 1516
C12N 121
C12N 1563
Abstract:
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic. alpha. -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa). sub. 2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.