Chiaho Shih Phones & Addresses
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1815 Orchard Country Ln, Houston, TX 77062 (281) 488-1819
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Philadelphia, PA
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Paoli, PA
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Galveston, TX
Publications
Us Patents
Viral Propagation System And Uses Thereof
View pageUS Patent:
20050153280, Jul 14, 2005
Filed:
Nov 12, 2004
Appl. No.:
10/988348
Inventors:
Chiaho Shih - Houston TX, US
International Classification:
C12Q001/70
C12N015/85
C12N015/86
C12N015/85
C12N015/86
US Classification:
435005000, 435455000, 435456000
Abstract:
Trans-differentiation induced by dexamethasone with or without oncostatin M results in cells that are capable of propagating and replicating hepatitis virus. Such trans-differentiated cells are useful for screening drugs that may affect the propagation and replication of hepatitis virus such as hepatitis B virus or hepatitis C virus.
Methods Of Viral Propagation And Gene Expression
View pageUS Patent:
51569701, Oct 20, 1992
Filed:
Aug 4, 1988
Appl. No.:
7/228600
Inventors:
Chiaho Shih - Paoli PA
Assignee:
Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 500
C12N 1500
C12N 1500
US Classification:
4352402
Abstract:
Novel methods for stable in vitro propagation of human hepatitis virus using non-human hepatocytes are disclosed. Also discussed are novel systems for efficient expression and secretion of foreign genes employing particular rat hepatoma cells.
Viral Defective Interfering Particles And Uses Thereof
View pageUS Patent:
59809019, Nov 9, 1999
Filed:
Sep 18, 1997
Appl. No.:
8/933480
Inventors:
Chiaho Shih - Houston TX
Ta-Tung Yuan - Galveston TX
Ta-Tung Yuan - Galveston TX
Assignee:
The Board of Regents of the University of Texas System - Austin TX
International Classification:
A61K 3929
A61K 3912
C12N 700
C12N 704
A61K 3912
C12N 700
C12N 704
US Classification:
4241891
Abstract:
The present invention provides a composition of matter comprising a defective interfering virus particle, wherein said particle naturally occurs in a human infection and wherein said particles has a naturally occurring core antigen internal deletion. Provided is a pharmaceutical composition, comprising defective interfering virus particle and a pharmaceutically acceptable carrier. Provided is a method for preparing defective interfering virus, comprising the steps of: (1) introduce a defective interfering virus and a complementing plasmid expressing a wild type virus core antigen and optionally containing a drug resistance gene, into a recipient cell; (2) selecting for stably transfected colonies; (3) growing the drug resistant cells and screening for the production of virus DNA replication; and (4) collecting defective interfering virus particles from the medium. Further provided is a vaccine, comprising a defective interfering virus particle.
Treating Diseases Associated With Pgc1-Alpha By Modulating Micrornas Mir-130A And Mir-130B
View pageUS Patent:
20160244755, Aug 25, 2016
Filed:
Sep 19, 2014
Appl. No.:
15/023300
Inventors:
Chiaho SHIH - Houston TX, US
Jyun-Yuan HUANG - Kaohsiung City, TW
- Nankang, Taipei, TW
Jyun-Yuan HUANG - Kaohsiung City, TW
- Nankang, Taipei, TW
International Classification:
C12N 15/113
Abstract:
Methods of regulating PGC1α and/or PGC1β, or treating diseases associated with PGC1α and/or PGC1β using a miR-130a RNA, miR-130b RNA, or a combination thereof, or using an antagomiR of miR-130a, an antagomiR of miR-130b, or both, which can be in the form of microRNA sponge or a locked nucleic acid (LNA).
Wikipedia References
Chiaho Shih
About:
Born:
09 January 1950
Work:
Chiaho Shih " Chiaho Shih " ( 施嘉和, born January 9, 1950 ) is a Distinguished Research Fellow in the Division of Infectious Disease & Immunology at Academia Sinica in Taiwan His research is in the area of Molecular virology, Viral hepatitis and Hepatocellular carcinoma, and Cancer.
Skills & Activities:
which is partially documented in Natalie Angiers book, Natural Obsessions, about her year spent in Weinberg's lab.