Charles J Stover

20020187160, Dec 12, 2002

May 24, 2002

10/153902

Daniel Stein - Silver Spring MD, US
Charles Stover - Mercer Island WA, US

University of Maryland

A61K039/12
A61K039/02
A61K039/002

424/186100, 424/190100, 424/191100

The invention relates to a hyperblebbing strain of which produces large amounts of blebs useful for production of blebosomes containing antigens for use as a vaccine delivery vehicle or as a diagnostic reagent. The invention also relates to a method for producing high levels of a desired protein in purified form using the hyperblebbing strain of , and to vaccine delivery systems containing the blebosomes expressing the desired antigen.

55830382, Dec 10, 1996

Nov 17, 1992

7/977630

Charles K. Stover - Silver Spring MD

MedImmune, Inc. - Gaithersburg MD

C12N 121
A61K 3904

4352523

An expression vector for expressing a protein or polypeptide in a bacterium, which comprises a first DNA sequence encoding at least a secretion signal of a lipoprotein, and a second DNA sequence encoding a protein or fragment thereof, or polypeptide or peptide heterologous to the bacterium which expresses the protein or fragment thereof, or polypeptide or peptide. The bacterium expresses a fusion protein a lipoprotein or lipoprotein segment and the protein or fragment thereof, or polypeptide or peptide heterologous to the bacterium which expresses the protein or fragment thereof, or polypeptide or peptide. Such expression vectors increase the immunogenicity of the protein or fragment thereof, or polypeptide or peptide by enabling the protein or fragment thereof, or polypeptide or peptide to be expressed on the surface of the bacterium. Bacteria which may be transformed with the expression vector include mycobacteria such as BCG. The expression vectors of the present invention may be employed in the formation of live bacterial vaccines against Lyme disease wherein the bacteria express a surface protein of Borrelia burgdorferi, the causative agent of Lyme disease.

57363676, Apr 7, 1998

Apr 20, 1995

8/425380

Shirley L. Haun - Gaithersburg MD
Charles K. Stover - Mercer Island WA
Graham Hatfull - Pittsburgh PA
Mark S. Hanson - Columbia MD
William R. Jacobs - City Island NY

MedImmune, Inc. - Gaithersburg MD

C12N 1500
C12N 120
C12N 1509
C12N 1563

4351723

A vector and a prokaryote transformed therewith which includes nucleic acid sequences which make possible the autocatalytic deletion of nucleotide sequences encoding an antibiotic resistance phenotype. The prokaryote can be a bacterium, and in particular a mycobacterium. Such transformed mycobacteria may be employed in vaccines, thereby eliminating the attendant risk of vaccines including antibiotic resistance markers.

61801119, Jan 30, 2001

May 19, 1998

9/081576

Daniel C. Stein - Silver Spring MD
Charles K. Stover - Mercer Island WA

University of Maryland - College Park MD

A61K 39095

4242491

The invention relates to a hyperblebbing strain of Neisseria gonorrhoeae which produces large amounts of blebs useful for production of blebosomes containing antigens for use as a vaccine delivery vehicle or as a diagnostic reagent. The invention also relates to a method for producing high levels of a desired protein in purified form using the hyperblebbing strain of N. gonorrhoeae, and to a vaccine delivery systems containing the blebosomes expressing the desired antigen.

20220177554, Jun 9, 2022

Nov 15, 2021

17/454837

- Cambridge, GB
Paul WARRENER - Gaithersburg MD, US
Charles STOVER - Gaithersburg MD, US
Bret SELLMAN - Gaithersburg MD, US
Ralph MINTER - Cambrige, GB
Sandrine GUILLARD - Cambridge, GB
Steven RUST - Cambridge, GB
Mladen TOMICH - Exton PA, US
Vignesh VENKATRAMAN - Cambridge, GB
Reena VARKEY - Gaithersburg MD, US
Li PENG - Gaithersburg MD, US
Melissa DAMSCHRODER - Gaithersburg MD, US
Partha S. CHOWDHURY - Gaithersburg MD, US
Nazzareno DIMASI - Gaithersburg MD, US
Ryan FLEMING - Gaithersburg MD, US
Binyam BEZABEH - Gaithersburg MD, US
Changshou GAO - Gaithersburg MD, US
Godfrey RAINEY - Gaithersburg MD, US
Cuihua GAO - Gaithersburg MD, US

C07K 16/12

This disclosure relates to combination therapies comprising anti-Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of infection.

20230079661, Mar 16, 2023

Aug 11, 2022

17/819199

- Gaithersburg MD, US
- Bellinzona, CH
Xiaodong XIAO - Gaithersburg MD, US
Davide CORTI - Bellinzona, CH
Elisabetta CAMERONI - Bellinzona, CH
Martina BELTRAMELLO - Bellinzona, CH
Gilad KAPLAN - Gaithersburg MD, US
Anna DeMARCO - Bellinzona, CH
Charles K. Stover - Gaithersburg MD, US

C07K 16/12
A61P 31/04
A61K 31/407
A61K 39/40

The present disclosure provides binding proteins (e.g., antibodies or antigen binding fragments thereof) that specifically bind to O2 and induce opsonophagocytic killing of (e.g., ) and/or protects mice from a lethal challenge. The present disclosure also provides methods of reducing (e.g., ) or treating or preventing (e.g., ) infection in a subject comprising administering the O2 binding proteins, (e.g., antibodies or antigen-binding fragments thereof) to the subject.

20210130442, May 6, 2021

Oct 19, 2020

17/073879

- Cambridge, GB
Paul G. WARRENER - Gaithersburg MD, US
Charles K. STOVER - Gaithersburg MD, US
Bret SELLMAN - Gaithersburg MD, US
Sandrine GUILLARD - Cambridge, GB
Ralph MINTER - Cambridge, GB
Steven RUST - Cambridge, GB
Mladen TOMICH - New York NY, US

C07K 16/12
A61K 47/68

This disclosure relates to an anti-Psl binding molecule and uses thereof, in particular in prevention and treatment of infection. Furthermore, the disclosure provides compositions and methods for preventing and treating infection.

20200317757, Oct 8, 2020

Feb 13, 2020

16/789790

- CAMBRIDGE, GB
Paul WARRENER - Gaithersburg MD, US
Charles STOVER - Gaithersburg MD, US
Bret SELLMAN - Gaithersburg MD, US
Ralph MINTER - Cambridge, GB
Sandrine GUILLARD - Cambridge, GB
Steven RUST - Cambridge, GB
Mladen TOMICH - Exton PA, US
Vignesh VENKATRAMAN - Cambridge, GB
Reena VARKEY - Gaithersburg MD, US
Li PENG - Gaithersburg MD, US
Melissa DAMSCHRODER - Gaithersburg MD, US
Partha S. CHOWDHURY - Gaithersburg MD, US
Nazzareno DIMASI - Gaithersburg MD, US
Ryan FLEMING - Gaithersburg MD, US
Binyam BEZABEH - Gaithersburg MD, US
Changshou GAO - Gaithersburg MD, US
Godfrey RAINEY - Gaithersburg MD, US
Cuihua GAO - Gaithersburg MD, US

C07K 16/12

This disclosure relates to combination therapies comprising anti-Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of infection.