Search

Chandrika P Govardhan

from Lexington, MA
Age ~65
Get Report
Also known as:
Chandrika P Pazhanisamy, Chandrika Govar Pazhanisamy, Chandrika P Govardham, Chandrika Govar
Phone and address:
9 Scotland Rd, Lexington, MA 02420
(781) 652-8764
Related to:
Subramania Pazhanisamy
Connected to:
Kenneth E Govas, 77Patricia E Govas, 76Ty Govatos, 79Aaron J Gove, 42Bill R Gove, 76Blakely I Gove, 42Carolyn A Gove, 78Christian Gove, 42Christopher C Gove, 39Craig B Gove, 45

Chandrika Govardhan Phones & Addresses

  • 9 Scotland Rd, Lexington, MA 02420 (781) 652-8764 (781) 863-8352
  • Middletown, CT
  • Burlington, MA
  • Waltham, MA
  • 9 Scotland Rd, Lexington, MA 02420 (781) 652-8764

Work

Company: Sanofi pasteur 2008 Position: Deputy director

Education

Degree: Ph. D School / High School: Wesleyan University 1980 to 1986 Specialities: Chemistry

Skills

Vaccine Formulation • Protein Chemistry and Biochemistry • Protein Formulation and Characterization • Assay Development • Monoclonal Antibodies • Vaccines • Protein Chemistry • Biochemistry • Biotechnology • Purification • Enzyme Kinetics • Formulation • Antibodies • Design of Experiments • Pharmaceutical Industry • Biopharmaceuticals • Characterization • Technology Transfer • Life Sciences • Drug Development • Gmp

Languages

English • Tamil

Ranks

Certificate: Project Management

Emails

c***n@yahoo.com

Industries

Biotechnology

Resumes

Resumes

Chandrika Govardhan Photo 1

Regulatory Cmc

View page
Location:
9 Scotland Rd, Lexington, MA 02420
Industry:
Biotechnology
Work:
Sanofi Pasteur since 2008
Deputy Director
Acambis Inc since 2008
Associate Director
Springbank Pharmaceuticals Apr 2007 - Jul 2008
Associate Director, New Technologies
Altus Pharmaceuticals Aug 1993 - Mar 2006
Principal Scientist
Education:
Wesleyan University 1980 - 1986
Ph. D, Chemistry
Skills:
Vaccine Formulation
Protein Chemistry and Biochemistry
Protein Formulation and Characterization
Assay Development
Monoclonal Antibodies
Vaccines
Protein Chemistry
Biochemistry
Biotechnology
Purification
Enzyme Kinetics
Formulation
Antibodies
Design of Experiments
Pharmaceutical Industry
Biopharmaceuticals
Characterization
Technology Transfer
Life Sciences
Drug Development
Gmp
Languages:
English
Tamil
Certifications:
Project Management

Publications

Us Patents

Methods Of Preparing Carbohydrate Crosslinked Glycoprotein Crystals

View page
US Patent:
6500933, Dec 31, 2002
Filed:
Mar 3, 2000
Appl. No.:
09/518849
Inventors:
Alexey L. Margolin - Newton MA
Chandrika P. Govardhan - Lexington MA
Kalevi J. Visuri - Kirkkonummi, FI
Sinikka S. Uotila - Espoo, FI
Assignee:
Altus Biologics Inc. - Cambridge MA
International Classification:
C07K 100
US Classification:
530395, 530402, 530408, 530813, 530815, 530816, 435 39, 435174, 435178, 435181, 4241931, 4241941, 514 8, 514 9
Abstract:
The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integrity of the glycoprotein backbone. According to one embodiment, this invention relates to methods for concentrating proteins that have been modified by carbohydrates and for releasing their activity at controlled rates. This invention also provides methods for producing carbohydrate crosslinked glycoprotein crystals and methods for using them in pharmaceutical formulations, vaccines, immunotherapeutics, personal care compositions, including cosmetics, veterinary pharmaceutical compositions and vaccines, foods, feeds, diagnostics, cleaning agents, including detergents and decontamination formulations. The physical and chemical characteristics of carbohydrate crosslinked glycoprotein crystals render them particularly useful as sorbents for separations, such as chiral chromatography, or affinity chromatographyâwhich are based on specific interactions between the active binding site of the glycoprotein component of the crystals and the substance or molecule of interest. Such characteristics also render carbohydrate crosslinked glycoprotein crystals useful as catalytic and binding components for the production of biosensing devices.

Carbohydrate Crosslinked Glycoprotein Crystals

View page
US Patent:
7087728, Aug 8, 2006
Filed:
Dec 23, 2002
Appl. No.:
10/329968
Inventors:
Alexey L Margolin - Newton MA, US
Chandrika P Govardhan - Lexington MA, US
Kalevi J Visuri - Kirkkonummi, FI
Sinikka S Uotila - Espoo, FI
Assignee:
Altus Pharmaceuticals Inc. - Cambridge MA
International Classification:
C07K 1/00
C12N 11/00
A61K 38/16
US Classification:
530395, 530402, 530813, 530815, 530816, 435174, 435178, 435181, 514 8
Abstract:
The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integrity of the glycoprotein backbone. According to one embodiment, this invention relates to methods for concentrating proteins that have been modified by carbohydrates and for releasing their activity at controlled rates. This invention also provides methods for producing carbohydrate crosslinked glycoprotein crystals and methods for using them in pharmaceutical formulations, vaccines, immunotherapeutics, personal care compositions, including cosmetics, veterinary pharmaceutical compositions and vaccines, foods, feeds, diagnostics, cleaning agents, including detergents and decontamination formulations. The physical and chemical characteristics of carbohydrate crosslinked glycoprotein crystals render them particularly useful as sorbents for separations, such as chiral chromatography, or affinity chromatography—which are based on specific interactions between the active binding site of the glycoprotein component of the crystals and the substance or molecule of interest. Such characteristics also render carbohydrate crosslinked glycoprotein crystals useful as catalytic and binding components for the production of biosensing devices.

Crystals Of Whole Antibodies And Fragments Thereof And Methods For Making And Using Them

View page
US Patent:
7833525, Nov 16, 2010
Filed:
Dec 26, 2001
Appl. No.:
10/034950
Inventors:
Bhami Shenoy - Woburn MA, US
Chandrika P. Govardhan - Lexington MA, US
Mark X. Yang - Newton MA, US
Alexey L. Margolin - Newton MA, US
International Classification:
A61K 39/395
A61K 39/00
G01N 31/00
US Classification:
4241301, 436 4, 4241781
Abstract:
This invention relates to crystals of whole antibodies and fragments thereof, and formulations and compositions comprising such crystals. More particularly, methods are provided for the crystallization of high concentrations of whole antibodies, and fragments thereof, in large batches, and for the preparation of stabilized whole antibody crystals for use alone, or in dry or slurry formulations or compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active whole antibody crystals.

Spherical Protein Particles And Methods For Making And Using Them

View page
US Patent:
7998477, Aug 16, 2011
Filed:
Dec 19, 2003
Appl. No.:
10/741861
Inventors:
Kirill Yakovlevsky - Cambridge MA, US
Michael Shamashkin - Somerville MA, US
Nazer Khalaf - Worcester MA, US
Chandrika P. Govardhan - Lexington MA, US
Chu W. Jung - Arlington MA, US
Assignee:
Althea Technologies Inc. - San Diego CA
International Classification:
A61K 39/395
US Classification:
4241301, 5303871, 530418, 977904
Abstract:
This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs. More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentrations of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs. The present invention further relates to methods using SPPs, spherical nanocrystalline composite particles or crystalline SPPs, or compositions or formulations comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs, for biomedical applications, including biological delivery to humans and animals.

Carbohydrate Crosslinked Glycoprotein Crystals

View page
US Patent:
20010008934, Jul 19, 2001
Filed:
May 19, 1999
Appl. No.:
09/314717
Inventors:
ALEXEY L. MARGOLIN - NEWTON MA, US
CHANDRIKA POORNA GOVARDHAN - LEXINGTON MA, US
KALEVI VISURI - KANTVIK, FI
International Classification:
C07K001/00
C07K014/00
C07K017/00
C08H001/00
C07K016/00
A61K038/16
A47G021/00
A47G021/08
C12Q001/06
C12N011/00
US Classification:
530/395000, 530/402000, 530/403000, 530/813000, 530/815000, 530/816000, 435/039000, 435/174000, 435/178000, 435/181000, 424/193100, 424/194100, 514/008000, 414/009000
Abstract:
The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integrity of the glycoprotein backbone. According to one embodiment, this invention relates to methods for concentrating proteins that have been modified by carbohydrates and for releasing their activity at controlled rates. This invention also provides methods for producing carbohydrate crosslinked glycoprotein crystals and methods for using them in pharmaceutical formulations, vaccines, immunotherapeutics, personal care compositions, including cosmetics, veterinary pharmaceutical compositions and vaccines, foods, feeds, diagnostics, cleaning agents, including detergents and decontamination formulations. The physical and chemical characteristics of carbohydrate crosslinked glycoprotein crystals render them particularly useful as sorbents for separations, such as chiral chromatography, or affinity chromatography—which are based on specific interactions between the active binding site of the glycoprotein component of the crystals and the substance or molecule of interest. Such characteristics also render carbohydrate crosslinked glycoprotein crystals useful as catalytic and binding components for the production of biosensing devices.

Daptomycin And Related Analogs In Crystalline Form

View page
US Patent:
20020111311, Aug 15, 2002
Filed:
Dec 18, 2001
Appl. No.:
10/024405
Inventors:
Chandrika Govardhan - Lexington MA, US
Nazer Khalaf - Worcester MA, US
International Classification:
A61K038/17
C07K007/64
US Classification:
514/012000, 530/359000, 530/317000, 514/009000
Abstract:
The invention provides the cyclic lipopeptide daptomycin and A-21978C analogs in crystalline form, methods of preparing the crystalline forms, compositions comprising the crystalline forms and methods of using these forms.

Carbohydrate Crosslinked Glycoprotein Crystals

View page
US Patent:
20020137899, Sep 26, 2002
Filed:
Jan 14, 2002
Appl. No.:
10/047605
Inventors:
Alexey Margolin - Newton MA, US
Chandrika Govardhan - Lexington MA, US
Kalevi Visuri - Kantvik, FI
Sinikka Uotila - Espoo, FI
Assignee:
Altus Biologics Inc.
International Classification:
A61K038/17
C07K014/435
US Classification:
530/395000, 514/008000
Abstract:
The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integrity of the glycoprotein backbone. According to one embodiment, this invention relates to methods for concentrating proteins that have been modified by carbohydrates and for releasing their activity at controlled rates. This invention also provides methods for producing carbohydrate crosslinked glycoprotein crystals and methods for using them in pharmaceutical formulations, vaccines, immunotherapeutics, personal care compositions, including cosmetics, veterinary pharmaceutical compositions and vaccines, foods, feeds, diagnostics, cleaning agents, including detergents and decontamination formulations. The physical and chemical characteristics of carbohydrate crosslinked glycoprotein crystals render them particularly useful as sorbents for separations, such as chiral chromatography, or affinity chromatography—which are based on specific interactions between the active binding site of the glycoprotein component of the crystals and the substance or molecule of interest. Such characteristics also render carbohydrate crosslinked glycoprotein crystals useful as catalytic and binding components for the production of biosensing devices.

Methods For Preparing Purified Daptomycin

View page
US Patent:
20030045484, Mar 6, 2003
Filed:
Dec 17, 2001
Appl. No.:
10/024701
Inventors:
Dennis Keith - Montclair NJ, US
Chandrika Govardhan - Lexington MA, US
Nazer Khalaf - Worcester MA, US
International Classification:
C07H017/08
A61K031/7048
US Classification:
514/028000, 536/007100
Abstract:
The present invention relates to methods of providing crystalline and crystal-like forms of daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying daptomycin.
Control profile
Chandrika P Govardhan from Lexington, MA, age ~65 Get Report